一三年度股东大会会.pptVIP

Development and Application of Computational Toxicology and Informatics Resources at theFDA CDER Office ofPharmaceutical Science The Informatics and Computational Safety Analysis Staff (ICSAS) Develops animal toxicology and clinical safety databases and data transformation algorithms Transforms data, developing human expert rules for converting toxicological and clinical adverse effects data into a form suitable for computer modeling Evaluates and promotes the use of quantitative structure activity relationship (QSAR) and data mining software Leverages by working with the scientific community and software developers to create QSAR predictive toxicology software using mechanisms such as Material Transfer Agreements (MTAs) and Cooperative Research and Development Agreements (CRADAs) ICSAS and the Critical Path Initiative Develop and supply new databases and predictive toxicology software tools to the pharmaceutical and chemical industry to improve the lead candidate screening process Develop better means to identify and eliminate compounds with potentially significant adverse properties early in the discovery and development process, thereby reducing the regulatory review burden for the FDA, CDER and other regulatory agencies Facilitate the review process by making better use of accumulated toxicological and human clinical knowledge. Reduce testing (and use of animals) by eliminating non-critical and redundant laboratory studies 5. Encourage the development of complementary software systems that can predict toxicity and adverse human effects through collaboration with software developers and the scientific community Currently Used Applications for ICSAS Computational Toxicology Technical Solutions for Sharing Data Sharing study results linked to molecular attributes that do not disclose the name or molecular structure of proprietary compounds Data linked to MDL-QSAR E-state descriptors or MULTICASE molecular fragments can supply useful molecular info