帕金森病的治疗2010_.pptVIP

帕金森病的治疗2010 一、PD治疗领域的研究 Parkinson J. An Essay on the sharking palsy. London: Snerwood, Neely and Jones, 1817. It is characterized by“involuntary tremulous”motion, with lessened muscular power, in parts not in action and even when supported, with a propensity to bend the trunk forward, and to pass from a walking to a running pace, the senses and intellect being uninjured. （不自主震颤动作伴肌力减弱，部分患者震颤不仅发生在运动时，而静止时也有；躯干前屈，步态越走越快，感觉和智能不受损害） Parkinson未提到僵直和运动缓慢，而强调肌力减退，感觉和智能不受损害 一、PD治疗领域的研究 1960-1967： 三位先驱的杰出贡献 Carlsson Hornykiewicz Cotzias 发现DA是脑内的神经递质，提出PD与