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Global Journal of Clinical Report，2015,Vol.2,No.1 /index.php/gjc r A randomized clinical study of Domestic clopidogrel lipoic acid and cilostazol in treatment of diabetic limbs complications 1 2 3 3 Zhu Shujin ,Li Xinlei ,Huo Hong ,Zhao Beier 1 The peoples liberation army 323 hospital, Xi’an, Shanxi, China 2 Guoyang county peoples hospital, Guoyang, Anhui, China 3 Suzhou city hospitals, Suzhou, Anhui, China Received: Nov, 19, 2014 Accepted: Feb, 11, 2015 Published: Apr, 25, 2015 DOI: 10.14725/gjcr.v2n1a941 URL: /10.14725/gjcr.v2n1a941 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Objective: To observe efficacy and safety of domestic clopidogrel cilostazol in treatment of diabetic limbs complications. Methods: 120 cases of diabetic patients with limb complications were randomly selected, including 60 cases of lower extremity arterial disease (PAD) and 60 patients with diabetic peripheral neuropathy (DPN) patients. According to the random number list, they were randomly divided into treatment group of 60 patients, DPN and PAD were given mecobalamin 0. 5mg / times , lipoic acid 500mg / d, alprostadil 10ug / d, DPN patients while giving epalrestat 50mg / times. The control group while giving cilostazol 0.1g, 2 times / d, plus clopidogrel treatment groups 150mg / d in the control group, based on continuous treatment for 8 weeks. Clinical evaluation of the two groups was made and conduction velocity of MNCV and SNCV was compared. Results: Analysis of DPN subgroup showed that the treatment group was efficient (73.4% vs 46.7%, P = 0.035), total efficiency (93.3% vs 73.3%, P = 0.038) were significantly higher, PAD subgroup analysis showed the