桥粒钙黏蛋白对皮肤屏障功能影响的研究进展.PDFVIP

·406 · 现代药物与临床 Drugs Clinic 第 31 卷 第 3 期 2016 年 3 月 桥粒钙黏蛋白对皮肤屏障功能影响的研究进展 * * 高 丽，庄朋伟 ，张艳军 天津中医药大学 天津市中药药理重点实验室，天津 300193 摘 要：在细胞与细胞之间，桥粒提供一种强大的黏附作用，将细胞与中间纤维骨架相连，使细胞间的连接更为牢固。桥粒钙 黏蛋白是一种 Ca2＋依赖型的黏附蛋白，主要存在于桥粒中，并且是构成桥粒的重要组成部分。桥粒钙黏蛋白与一些皮肤性疾病 息息相关，它能参与黏附并维持组织结构的完整性，一旦桥粒钙黏蛋白的表达下降使组织间黏附丧失，将会导致一些皮肤性疾 病如天疱疮、水疱性脓疱病和葡萄球菌性烫伤样皮肤综合症等的发生。桥粒钙黏蛋白家族成员具有多样性且各种蛋白在组织不 同部位的表达具有复杂性，将对桥粒钙黏蛋白家族的成员及其在皮肤疾病方面的性质和功能作一个较全面的综述。 关键词：桥粒钙黏蛋白；桥粒芯糖蛋白；桥粒芯胶蛋白；桥粒；皮肤屏障功能 中图分类号：R986 文献标志码：A 文章编号：1674 - 5515(2016)03 - 0406 - 05 DOI: 10.7501/j.issn.1674-5515.2016.03.032 Research progress on effect of desmosomes cadherins on skin barrier function GAO Li, ZHUANG Peng-wei, ZHANG Yan-jun Tianjin Key Laboratory of Pharmacology of Chinese Materia Medica, Tianjin University of Traditionnal Chinese Medicine, Tianjin 300193, China Abstract: Desmosomes provide a strong adhesion between the cells, and they link intracellularly to the intermediate filament cytoskeleton to make the junction more strong. The desmosomal cadherins are Ca2+-dependent adhesion proteins and exist in desmosomes, and are the important parts of desmosomes. The desmosomal cadherins are closely related to some skin diseases. They are involved in adhension and can maintain the integrity of the organizational structures. When the expression decrease of desmosomal cadherins results in adhesion fails, some skin disease such as pemphigus, bullous impetigo, and staphylococcal scalded skin syndrome, etc will occur. The family members of desmosomal cadherins have diversity and the expression in different parts of the tissues is complex. Therefore, this article will review the family members of desmosomal cadherins, and their properties and function in skin diseases. Key words: desmosomal cadherins; desmogleins; desmocollins; desmosomes; skin barrier function 细胞与细胞间的连接在多细胞组织和器官的发