6―氨基己酸联合尼莫地平注射液在蛛网膜下腔出血中应用效果.doc

6―氨基己酸联合尼莫地平注射液在蛛网膜下腔出血中应用效果 　　doi：10.3969/j.issn.1007-614x.2014.10.8 摘 要 目的：对蛛网膜下腔出血用6-氨基己酸联合尼莫地平注射液治疗的效果进行评价。方法：收治蛛网膜下腔出血患者98例，联合应用6-氨基己酸与尼莫地平注射液进行治疗，观察患者治疗3天、7天、2周后的治疗效果、并发症以及不良反应。结果：全组98例患者治疗3天、7天、2周后的总有效率分别69.39%、80.61%、92.86%，全组出现再出血17例（17.35%），出现脑缺血18例（18.37%），出现脑积水19例（19.39%）。治疗中出现恶心3例（3.06%），血压下降4例（4.08%），不良反应发生率7.14%。结论：对蛛网膜下腔出血病症采用6-氨基己酸和尼莫地平注射液进行联合治疗总有效率较高，同时能较好降低并发症的风险及再次出血的概率。 关键词 6-氨基己酸 尼莫地平 蛛网膜下腔出血 Application effect of 6-aminocaproic acid combined with nimodipine injection in subarachnoid hemorrhage Chen Jun The Internal Medicine of Chitianhua Group Hospital of Chishui City，Guizhou 564707 Abstract Objective：To explore the application effect of 6-aminocaproic acid combined with nimodipine injection in subarachnoid hemorrhage.Methods： 98 patients with subarachnoid hemorrhage were selected from 2010 March to 2013 June.They were treated by combined 6-aminocaproic acid and nimodipine injection.We observed the therapeutic effect，complications and adverse reactions of them in 3 days，7 days and 2 weeks after treatment.Results：In the whole group of 98 patients，the total effective rate for 3 days，7 days，2 weeks after treatment were 69.39%，80.61%，92.86% respectively；In all patients，17 cases had bleeding（17.35%）；18 cases had cerebral ischemia（18.37%）；19 cases had hydrocephalus（19.39%）.During the treatment，3 caseshad nausea（3.06%），4 cases had decreased blood pressure（4.08%），the incidence of adverse reaction was 7.14%.Conclusion：The total efficiency of 6-aminocaproic acid combined with nimodipine injection in subarachnoid hemorrhage is high.At the same time，it can reduce the risk of complications and the probability of bleeding again. Key words 6-aminocaproic acid；Nimodipine；Subarachnoid hemorrhage 人体血液在软脑膜血管破裂后流至蛛网膜下腔。血液对人体脑部神经产生挤压，因而患者临床上经常会有呕吐、头痛和意识改变等症状。对人体造成危害的脑血管痉挛和缺血性脑梗死等都是蛛网膜下腔出血的并发症。原发性蛛网膜下腔出血最常见的原因有先天性动脉瘤、脑血管畸形、高血压动脉硬化以及各种感染引起的动脉炎、血液病、抗凝治疗的并发症等[1]。控制患者继续出血是治疗该病的关键。为此，2010年3月-2013年6月收治蛛网膜下腔出血患者98例，采用6-氨基己酸和尼莫地平注射液进行治疗，现将结果报告如下。