添加载银纳米TiO2对硅橡胶抗菌性能及生物相容性的-中南大学学报.PDF

41 2 () Vol.41 No.2 2010 4 Journal of Central South University (Science and Technology) Apr. 2010 TiO 2 ( 410013) TiO2 TiO2 0~2.5% 140 1.5 h MTT (Rat fibroblast cells, L929)TiO2 0~2.0%TiO2 2.0%2.5% 100%TiO2 0 2.0% L929 L929 48 h TiO2 2.0% TiO2 TiO2 R318 A 1672−7207(2010)02−0526−06 Effect of addition of Ag-embedded nano-TiO on antibacterial 2 activity and biocompatibility of silicone rubber CHEN Liang-jian, HUANG Dong-mei, ZHANG Si-hui, YUAN Jian-ming (Third Xiangya Hospital, Central South University, Changsha 410013, China) Abstract: The effects of addition of Ag-embedded nano-TiO on antibacterial activity and biocompatibility of silicone 2 rubber in vitro were investigated. Ag-embedded nano-TiO2 was added to medical silicone rubber materials ranging from 0 to 2.5%, and the samples were vulcanized at 140 for 1.5 h. In vitro bacteria culture, the antibacterial effect of samples was tested. MTT assay method was used to evaluate the cytotoxicity of sample to the rat fibroblast cells L929. Cell culture method was used to assess the influence of sample on adhesion of L929. With the increase of Ag-embedded nano-TiO2 content, the inhibition rates of the samples increase. The inhibition rates of samples with the addition of 2.0% and 2.5% TiO are both 100%. The leaching liquors without TiO and with the addition of 2.0% TiO are nontoxic to