膜分离拆分对映异构体研究进展.PDFVIP

26 1 河 北 工 业 科 技 V ol . 26, No . 1 2009 1 H ebei J our nal of Indu str ial Science and T echno log y J an . 2009 1008- 1534( 2009) 0 1-0053- 05 , ( 河北科技大学化学与制药工程学院, 河北石家庄 0500 18) 对映异构体在药物中占有很大比例, 对映异构体药物在体内 呈现很大药效学药动学 差异单一对映异构体药物不仅可以使用药剂量减半, 而且具有疗效更好和更安全等显著优点 研究有效方法分离对映异构体具有显著现实意义手性拆分是获得单一对映异构体的重要途径, 在众多拆分方法中膜分离具有操作简单可连续生产放大过程易行等优点, 逐渐成为手性拆分技 术今后的发展方向对近年来采用液膜固膜等各种膜分离方法拆分对映异构体的研究进展进行 了综述 对映异构体; 手性拆分; 膜分离; 液膜; 固膜 T Q028 . 8 A R esearch developm ent of enant iom er separ at ion by m embrane process ZH A O L ei, ZH A O Ping ( Co lleg e of Chem ical and Ph arm aceut ical Eng ineering , H ebei U niv ersity o f Science and T echnolog y, Shij iazhuang H ebei 050018, China) Abstract: Enantio m er acco unt s f or qu ite larg e p ercentage in m edicines, w hich h as g reat diff erence in ph arm acodynam ics and ph arm aco kinetics . Singleness enantio m er m edicines not o nly m ake the do sage h alf , but al so possess bet ter curat ive eff ect and security, so ther e is notability reality m eaning in stu dying av ailability m etho d to separ ate enantio mer . A mong all kinds of sepa- r atio n m ethods, chir al separ atio n o f enantio m er is still o ne o f the m ain r outes to obtain sing leness enant iom er drug. M embra- nou s m ethods w ould be the fut ur e dir ect ion o f developm ent due to their sp ecif ic adv antag es, such as easy m anipulation , contin- uou s op eration mode and convenient scale up, et c. T his a rticle r eview s the separ ation pr inciple and sep arat ion pr ocess b ased on liqu id and so lid m embrane pr ocesses . Key words: enantio mer ; chir al sep aratio n; m embrane sep aration ; liqu id m embrane