温warm凉cool.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Herbal toxicity –non-toxicity 2 Long term toxicity 《齐医别录》Tingli葶苈、Shegan射干、Yuanhua芫花 “long term taking -- weakness” Yiyanghuo淫羊藿 “long-term-infertility” Fanshi矾石 “long-term-hurt bone” 《神农本草经》“Downward herbs—toxic no long-term use” The effects of 103 herbs long term using on toxic pathology study showed “Target organs”Liver、kidney、digestion system ; second: heart、 bone marrow 、Lung、CNS、endocrine. Herbal toxicity –non-toxicity 3 Allergy Symptoms： rash (erythra, quat)，anaphylactic shock Herbs：Jiangcan僵蚕、Wugong蜈蚣、Banmo斑蝥、Tubiecong土鳖虫、Langdu狼毒 Herbal toxicity –non-toxicity 4 malformationteratogenesis, mutant-genesis, cancer-genesis Interrupt embryo development--freak of naturemutantabnormality Cell mutant-- cancer Herbal toxicity –non-toxicity Leigongteng雷公藤：human--chromosome aberration. Binlang槟榔：rat/mouse—cancer Kuandonghua款冬花：rat --hemangioendothelioma血管内皮瘤 Qianliguan千里光：rat--liver cancer. Madouling马兜铃、Guangfangji广防己、Qingmuxiang青土香、Guanmuxiang关木通：Madouling Acid马兜铃酸，--human--chromosome aberration. chapter 3 Factors affect Herbal pharmcology Three factors：herbs itself; Human body; environment herbs：Herb source、collection season采收季节、store贮藏、concoct炮制、delivery mechanism of a medicine剂型 Human body：Age、Sex、Mental/physiological/ pathology/ genetic condition. Environment：climate、time时辰、location、 Herb itself 1 herbal breedvariety source品种与产地 example Dahuang--downward Zangye dahuang掌叶大黄、TangguDahuang唐古特大黄中，Dwonward function stronger; Huabei华北、Tiansan天山Dahuang—downward function weak. Location /region: soul climate, sunlight etc affect herbs growing, development… Example: Jinyinhua金银花 chlorogenic acid绿原酸，Grow in 河南山东Province 4%~7.5%，other provinces blow 3% of chlorogenic acid. Gengsen saponin more in Changbai mountain白山野山参. The concept“道地药材”original local herbs Sichuan province四川：Chuan-Beimu贝母、Chuan-fuzi附子、Chuan-huanglian黄连 Neimeng内蒙：Gancao甘草 Yu