左卡尼汀预防放疗所致肺癌患者心脏损伤的效果观察-肿瘤药学.pdfVIP

- 290 - 肿瘤药学 2013 年 8 月第 3 卷第 4 期　Anti-tumor Pharmacy, August 2013, Vol. 3, No. 4 ●临床交流● 左卡尼汀预防放疗所致肺癌患者心脏损伤 的效果观察 曹杰红，谭华清* （南华大学附属娄底市中心医院十二病室，湖南　娄底，4 17000 ） 摘要：目的　观察左卡尼汀注射液对放疗所致肺癌患者心脏损伤的预防作用。方法　将2011年4月~ 2013年4 月我院收治的80例肺癌患者随机分为观察组和对照组，每组各40例。对照组采用三维适形放疗，观察组在此基础上 给予左卡尼汀注射液。比较两组患者的心电图异常变化、心脏炎性反应的发生率、心脏主要不良症状以及放疗完成 率。结果　观察组心脏炎性反应的发生率和心电图异常的总发生率、心脏主要不良症状如胸闷、胸痛及心悸的发生率 均显著低于对照组（ 0.05）。观察组和对照组的放疗完成率为100.0％和82.5％，差异有统计学意义（ 0.05）。结论 P P 　左卡尼汀注射液可有效地预防放疗所致肺癌患者的心脏损伤，有利于放疗的顺利完成。 关键词：肺癌；放疗；心脏毒性；左卡尼汀 中图分类号：R734.2　文献标识码 ：A　文章编号：2095-1264（2013）04-0290-04 doi：10.3969/j.issn.2095-1264.2013.070 Observation on the Effects of L-carnitine in the Prevention of Radiotherapy induced Cardiotoxicity of Patients with Lung Cancer Cao Jiehong, Tan Huaqing* (12 wards, Loudi Central Hosp ital Aff iliated to University of South China, Loudi, Hunan, 417000, China) To observe the effects of L-carnitine in preventing radiotherapy-induced cardiotoxicity of patients Abstract: Objective with lung cancer. Methods Eighty patients with lung cancer admitted between April 2011 and April 2013 in our hospital were randomly divided into the observation group and control group, 40 cases in each. Patients in the control group were treated with dimensional conformal radiotherapy, and those in the observation group were given L-carnitine injection based on the treat- ment of the control group. The incidence rates of abnormal ECG changes, inflammatory heart rate, maj