碳青霉烯类耐药肠杆菌科细菌的研究进展.PDFVIP

传染病信息  2017年10月30日  第30卷  第5期  Infect Dis Info, Vol. 30, No. 5, October 30, 2017  ·257· ·导向与述评· 碳青霉烯类耐药肠杆菌科细菌的研究进展 林　迪，孙长贵     [摘要]　碳青霉烯类抗菌药物通常被认为是治疗常见革兰阴性杆菌严重感染最有效的抗菌药物，包括由耐药菌株引起 的感染。然而，随着碳青霉烯类抗菌药物在临床的广泛应用，产碳青霉烯酶的细菌也不断出现。肠杆菌科细菌是临床最常见 的革兰阴性杆菌，尤其是碳青霉烯类耐药肠杆菌科细菌（carbapenem-resistant Enterobacteriaceae, CRE ）的分离率在逐年增加。 CRE 传播速度快、范围广、致死率高，并且已在许多国家发生流行，对全球公共卫生构成重大威胁，应当引起高度重视与关注。 本文就CRE 流行情况、耐药机制、检测方法、治疗方案以及防控策略等作简要综述。     [关键词]　肠杆菌科；耐药性；碳青霉烯类；碳青霉烯酶；细菌感染     [中国图书资料分类号]　R378.2　　　　[文献标志码]　A　　　　[文章编号]  1007-8134(2017)05-0257-06　    　　DOI:10.3969/j.issn.1007-8134.2017.05.003 Research progress in carbapenem-resistant Enterobacteriaceae * LIN Di, SUN Chang-gui Department of Clinical Laboratory Science, The 117th Hospital of PLA, Hangzhou 310013, China *Corresponding author, E-mail: suncgui@163.com 　　[Abstract]　Carbapenem antibiotics are generally considered as the most potent antimicrobial agents in the treatment of severe infections caused by common gram-negative bacilli, including those caused by antimicrobial-resistant strains. However, as carbapenem antimicrobial agents are widely used in clinical practice, the bacteria producing carbapenemases are emerging. Enterobacteriaceae is regarded as the most common gram-negative bacilli in clinical practice, carbapenem-resistant enterobacteriaceae (CRE) isolation rate is also increasing year by year. CRE has a fast spread, wide range and high fatality rate. It has been popular in many countries, thus threatening global public health and attracting more attention. This article reviews the epidemics, drug resistance mechanism, detection methods, treatment options, prevention and control strategies of CRE. 　　[Key words]　Enterobacteriaceae; drug resistance; carbapenems; carbapenemases; bacterial infections 　　肠杆菌