紫杉醇化疗致眼部损伤的药学监护.pdfVIP

现代药物与临床 Drugs Clinic 第 31 卷 第 2 期 2016 年 2 月 ·233 · 紫杉醇化疗致眼部损伤的药学监护 1 2* 胡丽丽 ，宋晓坤 1. 徐州医学院附属医院 药学部，江苏 徐州 221006 2. 天津医科大学肿瘤医院 药学部，天津 300201 摘 要：目的 开展紫杉醇所致眼部损伤药学干预，探讨其发生机制，并提出防治建议。方法 分析紫杉醇眼部损伤与剂型 的关系，以紫杉醇化疗致眼部损伤个案为药学干预对象，监护患者眼部损伤不良反应，记录不同剂型紫杉醇致眼部损伤情况， 探讨减轻 ADR 的防治实施。结果 紫杉醇导致眼部损伤存在剂量相关性，紫杉醇脂质体替代紫杉醇注射液不能减轻眼部损 伤，白蛋白结合型紫杉醇有明确的眼损伤，避免特殊人群使用。结论 充分认识紫杉醇致眼部损伤机制及防治措施，开展有 效的药学干预，可使患者最大获益。 关键词：紫杉醇；剂型；眼部损伤；药学干预 中图分类号：R979.1 文献标志码：A 文章编号：1674 - 5515(2016)02 - 0233 - 04 DOI: 10.7501/j.issn.1674-5515.2016.02.025 Pharmaceutical care of eye damage induced by chemotherapy with paclitaxel 1 2 HU Li-li , SONG Xiao-kun 1. Department of Pharmacy, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China 2. Department of Pharmacy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300201, China Abstract : Objective To carry out the pharmaceutical intervention of eye damage caused by paclitaxel, and to explore the pathogenetic mechanism, and to offer precautionary and control suggestions. Methods To analyze the relationship between eye damage and dosage form of paclitaxel. A case of eye damage induced by chemotherapy with paclitaxel was used as pharmaceutical intervention. The adverse drug reaction (ADR) of eye damage was monitored, and eye damage induced by paclitaxel with different dosage forms was recorded, and to explore the precautionary and control implementation of reducing ADR. Results Eye damage caused by paclitaxel was dose-relatived. Paclitaxel Liposome instead of Paclitaxel Injection could not induce the eye damage. Abraxane had specific eye damage, and it should be avoided using for special crowd. Conclusion Fully understanding the mechanism and prevention measures of eye damage caused by paclitaxel and c