组织工程角膜材料研究进展中国病理生理杂志.pdfVIP

中国病理生理杂志 　Chinese Journal of Pathophysiology 　2002 ,18 ( 12) : 1557 - 1560 ·1557 · ( ) [文章编号] 　1000 - 4718 2002 12 - 1557 - 04 组织工程角膜材料研究进展 丁 　勇 , 　徐锦堂 , 　 陈建苏 (暨南大学医学院第一附属医院 , 广东 广州 510630) Advances in materials of keratoprosthesis and tissue engineering cornea DIN G Yong , XU Jin - tang , CHEN Jian - su ( The First Aff iliated Hosp ital , Medical College of J inan University , Guangz hou 510632 , China) 　　【A Revie w】　Although allograft corneal transplantation has made great progress ,keratoprothesis implan tation is the only one hope , for both the patients who has fleshy pannus corneal vitiligo and the patients with the failure corneal transplantation surgery whose far sight is only light perceptions to recover their eye sight . To gain success and reduce complications , a lot of work has been done in keratoprosthesis materials and type , but heterogeneity and bio - compatibility are not solved totally . Because of development in the cell culture and tis sue engineering , cornea ex vivo culture has gain a critical success. From cell option to carrier using , recon structed three dimensional culture and epithelium equivalent mimicked human corneas in key morphology and function and were used in basic and clinical investigation . This article reviews the development of materials of keratoprosthesis and tissue engineering cornea . 　　[ 关键词] 　角膜移植 ; 生物医学工程 ; 生物相容性材料 　　[ KEY WORDS] 　Corneal transplantation ; Biomedical engineering ; Biocompatible materials 　　[ 中图分类号] 　R31808 　　　　　[文献标识码] 　A 1 　人工角膜材料 力性而获得了普遍的应用 。聚乙烯共聚水凝胶能耐 人工角膜的发展经历了一个 曲折漫长的过程 , 受手术且能保持其透明性被视为一种理想的合成人 早在 1789 年 ,法国医生 Pelli