氨磷汀应用于MDS的病例分享黄宁.pptVIP

氨磷汀应用于MDS的病例分享 济南军区总医院血液科 黄 宁 保护骨髓造血干/祖细胞 通过抗氧化清除自由基，为DNA修复提供氢离子来保护正常细胞，减少放疗诱导产生的染色体不稳定 --------Dziegielewski J, Baulch JE, GoetzW, et al. WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free Radic BiolMed, 2008; 45:1674 – 1681 保护骨髓造血干/祖细胞 氨磷汀不仅可以保护红系、粒系及巨核系细胞, 同样也可以保护淋巴系细胞, 使接受放、化疗或自体干细胞移植后的造血细胞和淋巴细胞早期易于恢复 --------Thompson JS, Asmis R, Chu Y, et al. Amifostine prior t o lethal irradiation prevents allogeneic bone marrow engraftment in mice. Bone Marrow Transplant, 2008; 41:927 – 934 --------Provinciali M, Ciavattini A, Di Stefano G, et al. In vivo amifostine (WR-2721) prevents chemotherapy-induced apoptosis of peripheral blood lymphocytes from cancer patients. Life Sci, 1999; 64:1525-1532 --------Rick O, Beyer J, Schwella N, et al. Influence of amifostine on reconstruction of lymphocyte subpopulations after conventional and high dose chemotherapy in patients with germ cell tumors. Ann Hematal, 2002; 81:717-722 保护骨髓造血干/祖细胞 氨磷汀不仅保护正常的造血干细胞, 对造血支持细胞也具保护作用, 可保护 NHL病人的骨髓间充质干细胞 (MSC) , 减少 VP- 16化疗对 MSC的损伤, 而且对 MSC的增殖、凋亡、免疫表型及造血无显著影响 --------李秋柏,唐晓琼,赵智刚等. 阿米福汀在非霍奇金淋巴瘤患者骨髓间充质干细胞体外化疗损伤中的保护作用. 中华医学杂志, 2007; 87:812 - 815 抗血管形成活性 近年来有研究发现 ,氨磷汀具有抗血管生成作用, 可以抑制骨髓造血干/祖细胞分泌 VEGF --------Akel S M, AtoumMF, Saleh SA, et al . Amifostine exerts anti2 angiogenic activity and supp resses vascular endothelial growth factor secreted by hemopoietic stem/progenit or cells. Saudi Med J, 2005; 26:1523 - 1528 促进造血 氨磷汀可以促进接受放疗的小鼠和未放疗的正常人的骨髓造血, 促进骨髓红系、粒系、单核及巨核系细胞集落单位的形成及爆式集落形成单位BFU的形成, 使接受放、化疗或自体移植后的粒细胞早期易于恢复 --------Provinciali M, Ciavattini A, Di Stefano G, et al. In vivo amifostine (WR-2721) prevents chemotherapy-induced apoptosis of peripheral blood lymphocytes from cancer patients. Life Sci, 1999; 64:1525-1532 --------Rick O, Beyer J, Schwella N, et al. Influence of amifostine on reconstruction of lymphocyte subpopulations after conventional and high dose chemotherapy in