组蛋白糖基化修饰.pptVIP

O-GlcNAc is part of the histone code Kun Ming institute of botany, CAS Yang Yan Long Content 1. Historical Background of O- GlcNAc 2. The O-GlcNAcylation of histones 3. Role of histone O-GlcNAyclation 4. Discussion Historical Background of O- GlcNAc O-GlcNAc was first shown to be a major form of intracellular glycosylation in murine lymphocytes in 1984 O-Linked β-N-acetylglucosamine (O-GlcNAc) is a dynamic protein modification abundant within the nucleus and cytoplasm Chapter 18, Figure 1 a b Essentials of Glycobiology Second Edition Chapter 18, Figure 2 a b Essential