胺碘酮致甲状腺功能异常的诊治进展.pdfVIP

968 · · 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.5 MAR.2011 胺碘酮致甲状腺功能异常的诊治进展 许宇静 洪 侃△ （南京医科大学附属无锡人民医院内分泌代谢科 江苏无锡214023） 摘要：胺碘酮是治疗心律失常的常用药物。但由于其富含碘及自身固有的特性，可导致一系列甲状腺功能的紊乱，甚至引发明显 AIH 的甲状腺功能减退（甲减）或甲状腺功能亢进（甲亢）。对于胺碘酮所致甲减（ ）的诊断和治疗目前比较清晰，但对胺碘酮所致甲 AIT 亢（ ）的诊断、鉴别其亚型及治疗有一定的难度。 关键词：胺碘酮；甲状腺功能；诊断；治疗 R581 R972.2 A 1673-6273 2011 05-968-04 中图分类号： 文献标识码： 文章编号： （ ） The progress on the diagnosis and treatment of amiodarone-induced thyroid dysfunction XU Yu -j ing, HONG Kan△ (Dep artment of Endocrinology Metabolism Peop le s Hosp ital of Wuxi City Jiangsu Province 2 14023 China) ， ， ， ABSTRACT: Amiodarone is an effective medication approved for the treatment of cardiac arrhythmias. However, this drug has high iodine content,and this feature plus the intrinsic effects on the body which make amiodarone toxic to the thyroid gland would induce a series of disfunction even result in overt hypothyroidism or thyrotoxicosis. So far,the diagnosis and treatment of amiodarone-induced ， hypothyroidism(AIH) is clear and definite, whereas that of amiodarone-induced thyrotoxicosis(AIT) and the ability to distinguish between the subtypes of the diease have much more challenge. And confirming the subtype of AIT is instructive to the treatment. Key words: Amiodarone;thyroid function;diagnosis;treatment Chinese Library Classification(CLC): R581 R972.2 Document code: A Article ID:1673-6273(2011)05-968-04 1985 [1] 胺碘酮在 年始即被美国批准用于抗