70例头孢菌素类抗生素的不良反应临床调查分析.docVIP

精品论文 参考文献 70例头孢菌素类抗生素的不良反应临床调查分析 (商丘市第一人民医院西药房 河南商丘 476100) [摘要] 目的 分析70例头孢菌素类抗生素的不良反应临床表现。方法 将我院2014年9月—2015年12月收治的70例应用头孢菌素类抗生素患者进行研究，统计患者年龄、性别、抗生素给药途径、不良反应表现。结果 70例患者中10岁以下、60岁以上患者是不良反应多发群体，男性发生率为54.3%，女性发生率为45.7%，男、女服用头孢菌素类抗生素后不良反应发生率比较，无明显差异（P＞0.05）；静脉滴注头孢菌素类抗生素造成的不良反应发生率最高，高达54.3%；头孢菌素类抗生素引发的不良反应主要发生在皮肤、循环系统、呼吸系统、神经系统、消化系统、血液系统等，其中皮肤发生率最高，高达35.7%。结论 头孢菌素类抗生素引起的不良反应多发于儿童与老年患者，静脉给药易引发不良反应，主要表现为荨麻疹、瘙痒、红肿等皮肤症状；因此临床用药时需对患者体质、药物类型进行充分考虑，以减少不良反应发生风险，保证治疗效果。 [关键词] 头孢菌素类抗生素；不良反应；临床分析 Clinical investigation and analysis of 70 cases of adverse drug reactions of the patients with Hu Qingmei (Shangqiu First Peoples Hospital, Shangqiu, Henan 476100) [Abstract] Objective: to analyze the clinical manifestations of adverse reactions of 70 cases of the patients with. Methods 70 cases in our hospital from December 2015 to September 2014 were studied. The age, sex, the way of drug administration and adverse reaction were studied. Results 70 cases of patients under the age of 10, over the age of 60 patients with adverse reactions of multiple groups, male incidence rate was 54.3%, female incidence rate was 45.7%, male and female taking cephalosporin antibiotics after the incidence of adverse reactions compared, no significant difference (P gt; 0.05); intravenous injection head spore antibiotics caused adverse reaction rate is the highest, up to 54.3%; cephalosporins induced adverse reactions occurred mainly in skin, circulatory system, respiratory system, nervous system, digestive system, blood system and the skin was the highest and reached 35.7%. Conclusion cephalosporins induced adverse reactions in children and elderly patients, intravenous administration of easily lead to adverse reactions, mainly as skin hives, itching, swelling and other symptoms; therefore clinical need to take full account of the constitution of the patients and the type of drugs, to reduce the incidence of adverse reactions of risk, to ensure that the treatment eff