s100β蛋白测定在老年肺癌根治术后认知功能障碍评价中的临床价值研究.docVIP

精品论文 参考文献 S100β蛋白测定在老年肺癌根治术后认知功能障碍评价中的临床价值研究 中国人民解放军第一五三中心医院呼吸内科 河南 郑州 450042 【摘 要】目的：为了了解S100beta;蛋白与术后认知功能的关系，探索血清S100beta;蛋白水平测定在老年肺癌根治术后认知功能障碍评价中的临床价值。方法：采用前瞻性研究方法，选取我院近年来肺癌择期手术患者80例作为手术组，及同期健康体检者80例作为对照组，分别测定两组研究对象术前24h及术后30min、6h、24h、72h、1周血清S100beta;蛋白水平，同时对两组研究对象作术前24h及术后6h、24h、72h、1周的MMSE评分，所得结果以均数plusmn;标准差表示，并应用统计学软件进行统计分析。结果：手术组术后30min、6h、24h、72h血浆S100beta;蛋白水平较术前及同期对照组明显升高（Plt;0.05），表明术后脑损伤的存在。两组MMSE评分比较，手术组术后6h、24h、72h的MMSE评分较术前及同期对照组值明显降低（Plt;0.05），反映手术组患者术后早期认知功能障碍的存在，且评分越低认知功能障碍越严重。结论：血清S100beta;蛋白水平可作为反映术后脑损伤的指标，且血清S100beta;蛋白浓度与损伤程度具有相关性，检测血清S100beta;蛋白水平有利于评价术后认知功能障碍的严重程度，能指导老年肺癌根治术患者术后早期的认知功能障碍治疗及判断预后。 【关键词】老年；肺癌根治术后；S100beta;蛋白；认知功能障碍 Clinical Value of S100beta; protein determination in evaluating the cognitive dysfunction of elderly lung cancer radical postoperative Yehejiang (Department of Respiratory Medicine, The Peoples Liberation Army first fifty-three Central Hospital, Zhengzhou 450042，China) 【Abstract】Objective: To understand the relationship between protein and cognitive function in patients S100beta; explore S100beta; protein serum levels were measured in elderly lung cancer clinical value assessment of radical postoperative cognitive dysfunction. Methods: A prospective study of lung cancer patients in our hospital in recent years, 80 cases of elective surgery as the surgery gr- oup, and 80 cases of healthy volunteers as a control group, two groups of subjects were measured before surgery 24h, after 30min, 6h, 24h , 72h,1 week S100beta; serum protein levels and both groups before and after 24h 6h, 24h, 72h, 1 week MMSE score, the measured results are expressed as mean plusmn; standard deviation, and using statistical software for statistical analysis. Results: surgery group after 30min, 6h, 24h, 72h S100beta; plasma protein levels compared with preoperative and con- current control group was significantly higher (P lt;0.05), described the presence of postoperative brain damage. MMSE scores between the two groups over the same pe