11192的工艺路线评估.docx

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2017-12-19 发布于河南
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11192的工艺路线评估.docx

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11192的工艺路线评估

项目评估结论项目编号综合评估结论□可以做该项目，决定采用路线1 □ 公司不适宜做该项目人员配置本科及以下:____人硕士:__1___人博士:____人预计进度拉通工艺时间 _20-30___天20克样品时间 ____天工艺优化时间30-35_天完成询盘生产时间_____天成本情况（指研发阶段）原材料成本_____元人工成本_____元分析成本____元新增设备或仪器_____元合计_____元不确定因素建议难度系数Synthetic RouteReference (参考文献)操作步骤化合物A的合成化合物B的合成化合物D的合成Process StepQty (kg)Qty (lts)Stage 1Vent R1 and H1 to a caustic scrubberCharge DMF to R1650Charge DADHP to R1300Agitate the contents of R1 for 10-15 minutes.Cool the contents of R1 to less than 5C.Charge Phosphorous oxychloride to H11030Slowly add phosphorous oxylchloride to R1 maintaining the temperature below 25C.Maintain the contents at less than 30C for 30-45 minutes.Heat the contents to 70-75C over 2 hours.Agitate the contents of R1 for 48 hours at 70-75C.Charge toluene to R1 at 70-75C.1100Cool the contents of R1 to less than 5C.Charge water to H2300Cool the water in H2 to 2-5CCharge 25% of chilled water to R1, maintaining the temperature at less than 10C.750Transfer the contents of R1 to R2Charge toluene R1100Charge chilled water to R1200Slowly transfer the contents of R1 to R2, maintaining the contents of R2 below 10C.Slowly charge the remaining chilled water to R2, maintaining the contents at less than 10C.Charge 47% caustic solution to H32200Adjust the pH of R2 to pH 7.0 to 7.5 using caustic solution, maintaining temperature at less than 10C.Agitate the contents of R2 for 10-15 minutes.Check the pH of aqueous layer is pH 7.0-7.5.Heat the contents to 60-65C.Stir the contents at 60-65C for 30-45 minutes.Settle the contents of R2 for at least 45 minutes.Separate the aqueous layer to R3.Transfer the organic layer to R4.Transfer the aqueous layer back to R2.Charge toluene to R2.450Heat the contents to 60-65C.Stir the contents at 60-65C for 15-30 minutes.Settle the contents of R2 for at least 45 minutes.Separate the aqueous layer to R3.Transfer the organic layer from R4 to R2.Charge water to R21500Heat the contents to 60-65C.Stir the contents at 60-65C for 15-30 minutes.Settle the contents of R2 for