心血管英语译文.doc

The significance of plasma interleukin-8 variety in patients with coronary heart disease pre- and pro-coronary intervention??? ABSTRACT?? Coronary heart disease (CHD) has been the first critical disease of human being around the world. Percutaneous coronary intervention (PCI) has established an effective procedure for CHD. However, there were still some problems contributed to intervention related sever complications such as acute occlusion and restenosis pre- and pro-procedure.?? Since Ross initiatively suggested that atherosclerosis be a chronic inflammatory disease of the vessel wall in 1973, there have been progressive reports about the relations between inflammatory activation and coronary atherosclerosis. Recent data indicate that percutaneous transluminal coronary angioplasty (PTCA) can elicit an activation of inflammatory responses; preprocedural plasma C-reactive protein (CRP) level appear to be an independent predictor of complications and late restenosis in patients with PCI. However, CRP as a marker of inflammatory response cannot reflect the initial mechanism of inflammation and the relation between the inflammatory cells and the cytokines. Furthermore, the predictive value for clinical outcome or the guidance for prevention of complications was no precise. Lately study revealed that Interleukin-8 (IL-8), a powerful regulator of immunology and inflammation, is a mediator for the inflammation evoked by the tumor necrotic factor (TNF)、 interleukin-1 and interleukin-6. The major bioactivity of IL-8 is as an attractant activating neutrophiles to secrete adherent factors, further eliciting the up-graduation of β〓-integrin Mac-1 (CD11b/CD18) on neutrophiles. IL-8 is believed a key factor during the cascade of coagulation factors and cytokines. Therefore, The consistent studies on the regulations of IL-8 and other cytokines in patients with coronary heart disease pre- and pro-PCI were performed. The relationships between IL-8 and the early complicati