自由基相关细胞信号传导的研究进展_廖日滔.pdfVIP

Chinese Journal of Cell Biology 2014, 36(11): 1573–1583 DOI: 10.11844/cjcb.2014.11.0175 1 2 ( , 350002; , 310035) , , , DNA , , Ca2+Bcl-2 , , , ; ; Ca2+ ; ; Bcl-2 The Review on the Cell Signal Transduction Pathway Related to Free Radicals 1 2 1 2 * Liao Ritao , Guo Jingke , Li Bingjie , Rao Pingfan 1 2 ( Institute of Biotechnology, Fuzhou University, Fuzhou 350002, China ; Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences-Zhejiang Gongshang University Joint Centre for Food and Nutrition Research, Hangzhou 310035, China) Abstract Free radicals are molecules with an unpaired electron, and they are strong reactive. Free radicals are able to directly react with cellular components and result in cell damage. For example, free radicals could cause oxidation damage in mitochondrion through cardiolipin peroxidation and mtDNA peroxidation, and subsequently induce apoptosis. Moreover, free radicals enable to influence the signal transduction pathways including Ca2+ , protein phosphorylation, transcription factor and Bcl-2 gene, which play most important roles in apoptosis. Therefore, free radicals produce many biological effects, ranging widely from the regulation of physiological function to the increasing destructive changes related to pathology. Here we summary the generation and elimination of free radicals and their infl uence on signal transduction pathways, and attempt to achieve more comprehensive understanding of the signal transduction by free radicals. Key words free radical; signal transduction; C