复心汤对心衰大鼠心肌细胞因子TNF-α及BNP的影响.docVIP

精品论文 参考文献 复心汤对心衰大鼠心肌细胞因子TNF-α及BNP的影响 吉杨丹 王恒 余跃生 彭泽萍（通讯作者） 　　（黔南民族医学高等专科学校 贵州 都匀 558003） 　　【摘要】 目的：观察复心汤对心衰大鼠心肌细胞因子TNF-alpha;及BNP的影响，探讨其在心衰发展中的作用。方法：以健康Wistar SPF级雄性大鼠60只建立动物模型，随机分为4组：对照组、模型组、复心汤组与卡托普利组，分别给予相应处理。比较四组大鼠血清水平中的TNF-alpha;及BNP水平差异。结果各组间TNF-alpha;水平存在显著性差异(Plt;0.001)；模型组大鼠TNF-alpha;较对照组显著升高(Plt;0.05)；使用药物进行干预后，复心汤组与卡托普利组TNF-alpha;均明显，且复心汤组与卡托普利组相比差异具有显著性(Plt;0.05)。各组间BNP水平存在显著性差异(Plt;0.001)；模型组大鼠BNP水平明显高于对照组(Plt;0.05)；使用药物进行干预后，复心汤组与卡托普利组BNP水平均明显下降，且与卡托普利组相比，复心汤组下降更为显著(Plt;0.05)。结论：复心汤可显著下调心衰大鼠心肌细胞因子TNF-alpha;及BNP，保护心肌细胞，改善心功能，延缓心衰进程。 　　【关键词】 复心汤；心衰；TNF-alpha;；BNP 　　【中图分类号】R541.6 【文献标识码】A 【文章编号】2095-1752（2016）15-0054-02 　　Clinical effect of Fuxin decotion in the myocardial cell factor TNF-alpha; and BNP for rats with heart failure JiYangdan, Wang Heng, Yu Yuesheng, Peng Zeping. Qiannan Medical College For Nationalities, GuizhouProvince, Duyun558003, China 　　【Abstract】Objective To observe the impact and mechanism of Fuxin decotion in the myocardial cell factor TNF-alpha; and BNP for rats with heart failure.Method60 healthymale Wistar SPF rats were applied to establish the animal model. The rats were randomly divided into control group, model group, Fuxin group and Captopril group. The level of TNF-alpha; and BNP for four groups was compared. Result:The level of TNF-alpha; for each group was significantly different (P＜0.01); the level of TNF-alpha; for model group was higher than that of control group (P＜0.05); after intervention, the level of TNF-alpha; for Fuxin group and Captopril group was significantly different (P＜0.05); the level of BNP for each group was significantly different (P＜0.01); the level of BNP for model group was signficantly higher than that of control group (P＜0.05); after intervention, the level of BNP for Fuxin group was even lower than that of Captopril group (P＜0.05).Conclusion For rats with heart failure, Fuxin decotion can greatly reduce the level of myocardial cell factor TNF-alpha; and