2014～2016年神经内科重症监护病房铜绿假单胞菌感染定植情况及耐药性分析.docVIP

2014～2016年神经内科重症监护病房铜绿假单胞菌感染/定植情况及耐药性分析 殷琳 肖代雯 刘华 余春利 四川省医学科学院·四川省人民医院 西南医科大学 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 了神经内科重症监护病房 (ICU) 分离出铜绿假单胞菌感染/定植及耐药情况, 指导临床抗菌药物的合理使用。方法 查阅临床病历及临床微生物检验报告, 采用WHONET5.4软件统计分析近三年神经内科ICU铜绿假单胞菌感染/定植情况及药敏性。结果 62株铜绿假单胞菌主要来源于痰液标本, 其次是支气管灌洗液、尿液等;其中有34株为定植菌, 定植率54.84%;28株为感染菌, 感染率45.16%。62株铜绿假单胞菌均表现为多重耐药, 体外药敏结果显示对亚胺培南耐药率为35.48%;美罗培南耐药率为24.53%;哌拉西林/他唑巴坦耐药率为14.00%;头孢他啶耐药率为12.90%;左氧氟沙星8.20%。结论 应加强对铜绿假单胞菌感染/定植的监测并及时采取感染控制措施, 减少医院感染发生;根据铜绿假单胞菌对抗菌药物的药敏性, 合理选择抗菌药物, 减少多重耐药菌的产生。 关键词： 神经内科; ICU; 铜绿假单胞菌感染/定植药敏性; 收稿日期：2017-03-21 Status of infection, colonization and drug-resistance of Pseudomonas aeruginosa in intensive care unit of neurology department from 2014 to 2016 YIN Lin XIAO Dai-wen LIU Hua YU Chun-li Sichuan Academy of Medical Sciences Sichuan Provincial Peoples Hospital; Southwest Medical University; Abstract： Objective To understand the status of infection, colonization and drug-resistance of Pseudomonas aeruginosa in intensive care unit ( ICU) of neurology department from 2014 to 2016, in order to provide information for reasonable use of antibacterial agents and control of nosocomial infections.Methods After consulting clinical data and examination reports of clinical microbiology, status of infection, colonization and drug-resistance of Pseudomonas aeruginosa was statistically analyzed by using WHONET 5. 4 software.Results There were 62 strains of Pseudomonas aeruginosa isolated mainly from sputum, and subsequently from bronchoalveolar lavage fluid and urine in which 34 strains were colonization ( colonization rate = 54. 84%) and other 28 strains were infectious bacteria ( infectious rate = 45. 16%) .The 62 strains were all multiple resistant bacteria.The resistance rates for Imipenem, Meropenem, Piperacillin sodium/Tazobactam sodium, Ceftazidime and Levofloxacin were 35. 48%, 24. 53%, 14. 00%, 12. 90% and 8. 20%, respectively.Conclusion In order to reduce the generation