利用cfd模拟研究搅拌釜剪切应力对红豆杉细胞悬浮培养的-精细化工.docVIP

(磺酸化聚苯乙烯微球催化合成N-(乙氧基亚甲基)苯胺 刘少杰, 杜慧丽, 崔笑菲 (河北科技大学 化学与制药工程学院 化学工程系,河北 石家庄 050018) 摘要：首先通过无皂乳液聚合制得聚苯乙烯（PS）%，其活性优于强酸阳离子交换树脂(收率89%)，与对甲苯磺酸相当(收率98%)，且循环使用性能良好，循环使用5次后，收率仍可达到%左右 关键词：苯乙烯-苯乙烯磺酸共聚物微球；无皂乳液聚合；N-(乙氧基亚甲基)苯胺；可回收催化剂 中图分类号：TQ3341 文献标识码：A Synthesis of Ethyl N-phenylformimidate Catalyzed by Surface-sulfonated Polystyrene Microspheres LIU Shao-jie,DU Hui-li,CUI Xiao-fei (College of Chemical Pharmaceutical Engineering, Hebei University of Science Technology, Shijiazhuang 050018, Hebei,China) Abstract: The polystyrene (PS) seed emulsion was firstly prepared by soap-free emulsion polymerization. Styrene-styrene sulfonate copolymer microspheres (PS-NaSS@PS) with core-shell structure was then synthesized through polymerization of sodium p-styrenesulfonate in the PS seed emulsion. Followed by acidizing, surface sulfonated microspheres (PS-HSS@PS) was obtained. Ethyl N-phenylformimidate was synthesized with PS-HSS@PS as a recoverable catalyst. Its catalytic performance was compared with p-toluene sulfonic acid and commercially available strong acidic cation-exchange resin. The results showed that the sulfonic acid group content and the addition amount of PS-HSS@PS had a great influence on the catalytic performance. The catalytic activity of PS-HSS@ PS with high sulfonic acid content was excellent and the yield was up to 97%. The activity of PS-HSS@ PS was higher than that of srong acidic cation-exchange resin (89% of the yield), and comparable to p-toluene sulfonic acid (98% of the yield). Furthermore, PS-HSS@PS had excellent recyclability and the yield could reach 97% after 5 cycles. Key words: styrene-styrene sulfonate copolymer microspheres; soap-free emulsion polymerization; ethyl N-phenylformimidate; recyclable catalyst Foundation item: Natural Science Foundation of China N-(乙氧基亚甲基)苯胺及其衍生物作为重要的有机化工原料，广泛应用于医药、农药、染料等行业[1,2]。目前，酸催化下苯胺与原甲酸三乙酯的N-烷基化反应是合成N-(乙氧基亚甲基)苯胺的主要方法[3-6]。常规的酸催化剂包括无机酸（如：硫酸、氢卤酸、磷酸、氟磺酸）和有机酸（如：对甲苯磺酸、烷基磺酸等）。小分子无机酸在反应