麻省理工学院 生物材料课程 lecture 20 Drug Delivery Controlled Release III.pdf

3.051J/20.340J 1 Lecture 20 Drug Delivery: Controlled Release III Delivery Methods 1. Transdermal Drug delivery through the skin to systemic circulation traditional: crèmes/ointments novel: controlled release patches Transdermal Advantages: ¾effective systemic delivery (vs. GI) ¾high patient compliance ¾constant rate release (membrane-based) ¾easily terminated (patch removal) Device Designs a) membrane based laminated layers Metallized polymer drug reservoir backing (PET, PE, PP) (mineral oil or polyisobutylene) polymer membrane (PP, PVC, PAN, pressure-sensitive EVA, silicone) adhesive (PIB) peel strip 3.051J/20.340J 2 ⇒ Release rate constant (rate-limited by diffusion through membrane) b) monolithic patch Metallized polymer backing (PET, PE, PP) drug reservoir (polymer) drug crystals pressure-sensitive adhesive (PIB) ⇒ C0 CS Drug dissolution in polymer matrix controls release rate Disadvantages to Transdermal Delivery a) low skin permeability to drugs stratum corneum ~10-15 µm (dead tissue, lipid pore/follicle