液体物料冷冻干燥的几点事项研究.pdf

液体物料冷冻干燥的几点事项 王维陈国华 (香港科技大学化工系香港九龙清水湾) 摘要：液体物料冷冻干燥广泛应用于制药工业。其过程的重要性正赢得世界范围的研究 兴趣。不断增长的文献已证明科学手段能够用最少的试差来提高产品质量。过程的建立和规划 需要系统地理解冷冻、冷冻干燥、材料科学和质热传递等物理化学过程。根据近二十余年的出 版物，本文就液体物料冷冻干燥呈上一个简要的回顾和评述，并为读者整理出几点注意事项以 备将来研究和应用之需。 关键词：冷冻干燥液体物料共晶玻璃化转变赋形剂传质传热 IssuesinFreeze of Solutions Drying／LyophilizationAqueous Wei GuohuaChen Wang Chemical and (Departmentof Engineering,TheHongKongUniversityofScienceTechnology, Water Clear Bay,Kowloon,HongKong) Abstract：Freezeof solutionsis usedin dryingaqueous widely pharmaceuticalindustry．The increased ofthe is aworldwideinterestofresearch．A of processgaining growingbody importance scientific callresultin literaturehasdemonstratedthatthe approach improvedproductquality、衍tll trialanderror needa minimum and developmentsystematical empiricism．Formulationprocess freeze materialsdenceandthe ofthe of and physicalchemistryfreezing drying，the understanding of and onfreeze of mechanismsheat masstransfer．This abriefreview clrying paperpresents issuesof solutionsbasedon inthe fewdecades，and the aqueous publicationspast gears process towardsreadersinneedoffutureresearchand appUcafion．