健脾祛痰化瘀法防治动脉粥样硬化的临床研究进展-环球中医药.PDFVIP

摇1130 环球中医药2015年9月第8卷第9期摇 Global Traditional Chinese Medicine,September2015,Vol郾8,No郾9 ·综述 · 健脾祛痰化瘀法防治动脉粥样硬化的临床 研究进展 杨祎摇 司晓雪摇 邵楚茜摇 陈阳摇 赵丹玉摇 贾连群 揖摘要铱摇 对健脾祛痰化瘀法防治动脉粥样硬化的研究进行了文献整理和分析,以健脾、祛痰、 化瘀、动脉粥样硬化等为主题词进行了文献检索。 从血脂、免疫炎症、抗氧化和血管张力调节这4方 面总结了中药防治动脉粥样硬化的研究进展。 并且从上述4方面内容,对近10年来的动物实验和 临床随机对照实验进行了分析归纳。 健脾祛痰化瘀类方剂对动脉粥样硬化患者的血脂紊乱状态有 显著地纠正作用,并且也有抗炎、抗氧化应激与舒张血管作用。 进一步探讨了此类方剂防治动脉粥 样硬化的优势,以及开发此类方剂对于中医药防治动脉粥样硬化的广阔前景。 揖关键词铱摇 健脾;摇 化痰;摇 祛瘀;摇 动脉粥样硬化 揖中图分类号铱摇 R259摇 揖文献标识码铱摇 A摇 doi:10郾3969/ j郾issn郾1674鄄1749郾2015郾09郾030 Advancesintheclinical researchesof treatingatherosclerosisviathemethodofinvigoratingspleen, removingphlegm and eliminatingblood statisis摇 YANG Yi,SIXiao鄄xue,SHAO Chu鄄qian,et al.摇 The First Clinical College,Liaoning University of Chinese Medicine ,Shenyang 110847,China Corresponding author:JIA Lian鄄qun ,E鄄mail:Jlq鄄8@163.com 揖Abstract铱摇 In this review,currentresearchesontheTCM drugtherapiesof atherosclerosisviathe methodofinvigoratingspleen,removingphlegmandeliminatingstagnatedbloodweresummarizedandan鄄 alyzed.These methods and atherosclerosis were used as key words for literature search. We analyze animal experiments and RCT studies of the recent 10 years in4 aspects:inflammations,dyslipidemia,an鄄 tioxidation as well as angiotasis regulation.It turns out that:this kind of therapy plays a very important role in correcting dyslipidemia,anti鄄inflammtion as well as antioxidation and vasodilatation.However,our scholars concentrate more on its correction of dyslipidemia.We also further discuss the advantages of this therapy and its spectacular prospects for treating and protecting atherosclerosis. 揖Key words铱摇 Invigorating spleen;摇 Removing phlegm;摇 Eliminating blood stasis;摇 Atherosclerosis 摇 摇 动脉粥样硬化(atherosclorosis,AS)是心肌梗 代谢异常、慢性炎症、氧化应激和血管内皮功能紊 死,缺血性中风和周围血管病等一系列疾病的潜在 乱密切相关。 中医认为,脾虚失运