中国特发性膜性肾病患者长期预后及危险因素分析.PDFVIP

20 1 2011 2 目的: ( IMN), IMN , IMN 方法: MN 1990 2005, , 2 IMN , 结果: 21 IMN , 19 ~ 83 , 585% 5 10 15 968% , 930% 855% , (P 005)( 1096 m ol/L, P 001) Cox: , 50 (ESRF) ; ESRF Cox IMN ESRF , ESRF, 结论: IMN , IMN ESRF Longterm outcome and prognositc factors of indiopathicmembranous nephropathy in Chinesepopulation Z UO K e, W U Yan, LI Sh ij un, ZOU Shalin, X U F eng, ZEN G Caihong, LI U Zh ihong R esarch Ins i u e of N ep hro logy, J inling H osp i al, N anj ing Univ ersi y School of M ed ic ine, N anj ing 210002, Ch ina Corresp onding au hor: LI U Zh ihong (E m ail: zh ihongliu@ ho m ail. com ) ABSTRACT Objective:To investigate the prognosis and risk factors in Ch inese patientsw ith idiopath icm em branous nephropathy ( IMN) retrospectively. M ethodology: A ll patients w ere adm itted to Nanjing Institution of Nephrology from January 1990 to December 2005 w ith b iopsy proven IMN, and at least 24 m onths fellowup in this retrospective chart review. Their clinical features and pathologic changesw ere collected. Results:A total of 21 patien tsw ere enrolled in the study. The agew as ranged from 19 to 83 years old, w ith m ale ratio 585% . The overall renal survival rate w as 968% , 930% and 855% at 5, 10 and 15 years after renal b iopsy, respectively. When the clinical and pathologic features at the tmi e of biopsy w ere evaluated, the patientsw ith hypertens ion (P = 0012) and elevated serum creatin ine ( SC r, defined as SCr 1096 m ol/ l, P 0001) had worse prognosis. Cox univariate analysis showed that hypertension, age 50 years and elevated SC rw ere clin ical risk factors, and tubulointest