洛沙坦对阿霉素致大鼠慢性肾脏损害的长期保护作用-中南大学学报.PDFVIP

2002, 27( 4) BULL HUNAN MED UNIV 305 李志辉, 易著文 ( 中南大学湘雅二医院小儿肾脏病研究室, 长沙 4100 11) [ ] 目的: 探讨洛沙坦对阿霉素肾病鼠慢性肾脏损害的长期保护作用 寻找 一种研究肾素血管紧张素系统 ( RAS) 在肾脏慢性损害中的机制较为理想的动物模型方法: 72 只SD 大鼠随机分为对照组肾病组 干预组分2 次( 间隔20 d) 自其尾静脉注射阿霉素( 每次2 mg kg- 1 ) 构建肾病慢性病理进展模型, 洛沙坦10 mg( kg d) 灌胃进行干 预每4 周杀鼠一批观察大鼠肾脏重体重比值尿蛋白血尿素氮肌酐白蛋白胆固醇 肾脏病理结果: 24 h 尿 蛋白定量以肾病组为最高, 对照组为最低( P 0. 01) ; 血尿素氮血肌酐肾脏重体重比值肾小球硬化评分 肾小管 间质病理损害评分均以肾病组为最高, 对照组为最低( 均P 0. 01) 结论: 洛沙坦能够长期减轻阿霉素肾病鼠的慢 性肾脏损害; 阿霉素肾病鼠是一种研究RAS 导致肾损害的较为理想的动物模型 [ ] 肾素血管紧张素系统; 肾脏损害; 疾病模型, 动物; 鼠 [ ] R692 [ ] A [ ] 2002) Effect of losartan on the longterm renal protection of adriamycininduced nephropathy rats LI Zh hu , YI Zhuwen ( Laboratory of Pediatric Nep hrol ogy , Second X iangya H ospital , Central South Universi ty , Changsha 410011, China ) Abstract: Obj ective To study the effect of losartan on the longterm renal protect on for adr amyc nn duced nephropathy rats and to prov de an an mal model for the study of ren nang ot ens n systemnduced chron c progress ve k dney damage. Methods Seventytwo rats were randomly d v ded nto three groups( nephropathy, - 1 treated, and control groups) . Adr amyc n ( 2 mg kg ) was ntravenously adm n stered to the rats tw ce at a 20 day nterval. The treated group rece ved the ang otens n ! Type 1spec f c receptor antagon st losartan [ 10 mg ( kg d) ] by gastr c perfus on every day. An mals were k lled every 4 weeks. Blood b ochem cal analyses ( creat n ne, urea n trogen , album n , and