心律调节基因与抗心律失常中药靶标研究进展.PDFVIP

中草药 =q==e=a 第 QT 卷 第 N 期 =OMNS 年 N 月 ·NSR · 心律调节基因与抗心律失常中药靶标研究进展 1, 2 1, 2 1, 2 1, 2* 朱 莉 ，王泰一 ，崔 英 ，朱 彦 1. 天津中医药大学 天津市现代中药国家重点实验室，天津 300193 2. 天津国际生物医药联合研究院 中药新药研发中心，天津 300457 摘 要：心律失常是心血管疾病中一类重要的疾病，严重威胁着人类的健康。抗心律失常药物多为离子通道阻滞剂，存在效 率低的特点，并伴随严重的副作用。因此，对药物作用机制的深入研究并发展新的治疗策略，成为抗心律失常药物研究的新 热点。后基因组学加速了对基因突变、基因多态性、基因表达量变化及表观遗传学改变的理解和认识，它们在心律失常的发 生和发展过程中同样起着重要作用。而传统中药在治疗心律失常方面因其疗效显著、副作用少等优势，受到越来越多的关注。 就目前与心律失常相关的基因及其对应疾病进行概述，并从中药复方及其有效成分调节异常表达基因的角度，对现有中药抗 心律失常的可能靶点进行总结。以期为中药抗心律失常药理学研究提供借鉴。 关键词：中药；抗心律失常；基因；靶点；心血管疾病 中图分类号：R285 文献标志码：A 文章编号：0253 - 2670(2016)01 - 0165 - 10 alfW 10.7501/j.issn.0253-2670.2016.01.025 o=== J == ==J= ZHU Li1, 2, WANG Tai-yi1, 2, CUI Ying1, 2, ZHU Yan1, 2 1. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2. Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China W Cardiac arrhythmia is one of the most common types of cardiovascular diseases that seriously threaten human health. Presently, ion channel blockers are the main options for the treatment of cardiac arrhythmia. However, limited effectiveness and significant adverse effects severely tarnish their clinical application. Therefore, new anti-arrhythmic strategies and agents are urgently in demand. Post-genome era has paved the way for the accelerated discovery of novel gene mutations, gene polymorphisms and the change of gene expression and epigenetics that are attributable to cardiac arrhythmia. Chinese materia medica (CMM), known for its greater efficacy and less side effects, is a promising resource for novel anti-arrhythmic agents. This