喜炎平注射液对Beagle心电图的影响-中国试验动物学报.DOCVIP

喜炎平注射液对Beagle犬心电图的影响 齐卫红1,王超1,李欣1,张琳1,刘运强2,李伟1 (1.中国食品药品检定研究院，北京 100050；2.江西青峰药业有限公司，江西省赣州市 341000) 【摘要】目的 研究喜炎平注射液对Beagle犬心电图的影响。方法 将 24只Beagle犬随机分为阴性对照组（0mg/kg）、低剂量组（15mg/kg）、中剂量组（75mg/kg）、高剂量组（250mg/kg），每组6只，雌雄各半。每天一次，连续28天静脉点滴喜炎平注射液，给药体积是20mL/kg。，并设置恢复期14天。测定不同时期Ⅱ导联心电图。计算心率、P-R间期、Q-T间期、P波振幅、Q波振幅、R波振幅、S波振幅、ST振幅、T波振幅等指标，并同期取血测定血清生化学指标,观察对主要脏器的影响。结果 检疫期，24犬心电图各项指标均在正常值范围之内。高剂量组P-R间期时间延长。给药中期，给药结束后及恢复期各项指标未见异常。结论 喜炎平注射液对Beagle犬心电图无明显影响。 【关键词】喜炎平注射液; Beagle犬; 心电图 Effects of XiYanPing Injection on Electrocardiogram of Beagle Dogs QI Wei-hong1，WANG Chao1，LI Xin1， ZHANG Lin1，LIU Yun-qiang2，LI Wei1 （1.National Institutes for Food and Drug Control，Beijing 100050,china; 2 Jiangxi Qingfeng Pharmaceutical Limited Company, Ganzhou, Jiangxi,341000,china） [Abtract] objective To study the effect of Xi Yanping injection on electrocardiogram in Beagle dogs. Methods 24 Beagle dogs were divided into negative control group (0 mg/kg), low-dose group (15 mg/kg), middle-dose group (75 mg/kg), high-dose group (250 mg/kg) .Each group consist of 3 animals/sex/group, all animals were administrated by intravenous drip at 20 mL/kg once a day. Administration period was 28-days with 14-days recovery phase. Animals LeadⅡ electrocardiogram (ECG) was measured during quanrantine, administration and recovery phase. The following parameters included heart rate, P -R interval，Q - T interval, P, Q, R S wave amplitude and ST and T wave amplitude were determined， serum biochemical parameters were measured to evaluate the effect on main organs. Results All parameters of quarantine period were fell in the normal limit. After the first administration, heart rate decrease was found in low dose group and P-R interval prolongation was found in high dose group. No abnormal was found in dose metaphase，end of dose stage and recovery stage. Conclusion XiYanPing injection had no obvious influence on ECG of Beagle dog. 【Key words】XiYanPing Injection; Beagle dogs; Electrocardiogram (ECG) [基金项目]国