干扰素联合炎琥宁治疗小儿手足口病的临床效果观察 戴蔷蕾李晶.docVIP

精品论文 参考文献 干扰素联合炎琥宁治疗小儿手足口病的临床效果观察 戴蔷蕾李晶 戴蔷蕾　李　晶　（深圳市儿童医院　广东深圳　18026） 　　[ 摘　要]　目的：观察干扰素联合炎琥宁治疗小儿手足口病的临床效果，探讨小儿手足口病的临床有效治疗方案。方法：选 择患有手足口病的住院患儿166 例，按自愿原则，将52 例患儿分为A 组，采用干扰素治疗；将56 例患儿分为B 组，采用炎琥宁治 疗；将58 例患儿分为C 组，采用干扰素联合炎琥宁治疗。比较各组患儿退热时间、手足疱疹消退时间、口腔溃疡愈合时间、平均 住院时间及用药后临床效果。结果：单一用药组在用药后临床表现及临床效果比较无显著性差异（P ＞ 0.05）；联合用药组与单一 用药组在用药后临床表现及临床效果方面比较具有统计学意义（P＜ 0.05）。结论：干扰素联合炎琥宁治疗小儿手足口病临床效果 好，应作为小儿手足口病的首选治疗方法。 　　[ 关键词]　干扰素；炎琥宁；小儿；手足口病 　　Abstract: Objective: To observe the clinical effects of interferon combined with andrographolide in treatment of children hand, foot and mouth disease and discuss clinically effective treatment of it. Methods: Collect 166 children with hand, foot and mouth disease. According to the principle of voluntary,52 children were divided into A group with interferon treatment;56 children were divided into B group with andrographolide treatment; 58 children were divided into Cgroup with interferon combined with andrographolide treatment. Comparing cooling time, hand and foot herpes regression time, mouth ulcer healing, average length of stay and clinical results after treatment of every group. Results: There was no significant difference(Pgt;0.05) in single agent groups. Combination group and single agent group have a significant statistical significance(Plt;0.05) in the clinical manifestations and clinical effects after treatment. Conclusion: There were good clinical effects in treatment of children hand, foot and mouth disease by useing interferon combined with andrographolide, it should be regard as the preferred treatment in children hand, foot and mouth disease. Key Words: Interferon; Andrographolide; Children; Hand; Foot and Mouth Disease 　　[ 中图分类号]　R969.4 [ 文献标识码]　A [文章编号]　1004-1620（2015）10-039-02 　　手足口病（hand，foot and mouth disease，HFMD）是一种 由肠道病毒引起的出疹性疾病，具有传播快、感染性强、可 在儿童中呈散发或暴发流行等特点。近年来，HFMD患者出现 增多的趋势，特别是在儿童聚居地[1]。手足口病是由肠道病毒 EV71、柯萨奇A16 病毒及其他肠道病毒感染引起的，以发热、 手足、臀部水疱、斑丘疹及口腔疱疹、溃疡为主要表现的临床 综合征[2]。近年来，本病有增多及严重的趋势，我国于2008 年 将手足口病列为法定丙类传染病进行管理。手足口病一般症状 较轻，