应用奥美拉唑、泮托拉唑和雷贝拉唑治疗胃溃疡的疗效对比.docVIP

精品论文 参考文献 应用奥美拉唑、泮托拉唑和雷贝拉唑治疗胃溃疡的疗效对比 上海复旦大学附属金山医院普外科（刘景田 朱丹凤）201508 上海复旦大学附属华山医院普外科 (陈宗祐) 200040 [摘要]目的：对比分析奥美拉唑、雷贝拉唑以及泮托拉唑用于胃溃疡穿孔术后患者的临床治疗效果。方法：随机选取2013年7月至2015年8月本院收治的胃溃疡的患者90例进行分组对照研究，按照随机双盲法原则将本组患者分为三组，即治疗组1、治疗组2和治疗组3，各有病例30例，治疗组1采用奥美拉唑治疗，治疗组2采用雷贝拉唑治疗，治疗组3采用泮托拉唑治疗，然后对比分析三组患者的临床治疗效果，同时观察不良反应发生情况。结果：治疗组1、2、3临床总有效率分别为93.33%、93.33%和90.00%。各组组间统计学分析差异并无显著性（P＞0.05），但治疗组3对于腹胀的缓解效果显著优于其他两组，并且差异具有统计学意义（P＜0.05）；治疗组1对于嗳气的缓解效果明显较其他两组好，且差异具有显著性（P＜0.05），且治疗组1不良反应发生率显著低于其他两组，比较差异具存在显著性（P＜0.05）。结论：奥美拉唑、雷贝拉唑以及泮托拉唑对于胃溃疡均具有较好的临床疗效，但相比之下，奥美拉唑用于本病治疗产生的副作用较少，安全性相对较高，可作为胃溃疡临床药物治疗的首选。 [Abstract] Objective: To compare the clinical therapeutic effect of omeprazole, rabeprazole and pantoprazole for ulcer. Methods: Randomly selected in July 2013 to August 2015, 90 patients with gastric ulcer patients were admitted to our hospital group controlled study, randomized double-blind method in accordance with the principles of this group of patients were divided into three groups, namely treatment group 1 and group 2 treatment and 3 treatment groups, each with 30 cases, the treatment group 1 omeprazole treatment group 2 uses rabeprazole treatment group 3 using pantoprazole, and comparative analysis of the three groups of patients with clinical treatment effects observed adverse events. Results: The clinical total efficiency of 1,2,3 93.33%, 93.33% and 90.00%, respectively. Statistical analysis of the differences between the groups groups no significant (Pgt; 0.05), but the treatment group 3 For ease bloating effect significantly better than the other two groups, and the difference was statistically significant (P lt;0.05); the treatment group for belching Mitigating the effect of significantly better than the other two groups, and the difference was significant (P lt;0.05), treatment group 1 and incidence of adverse events was significantly lower than the other two groups, the difference with the presence of significant (P lt;0.05). Conclusion: omeprazole, rabeprazole and pantoprazole