Priming cancer cells for drug resistance: role of the fibroblast niche.pdfVIP

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Priming cancer cells for drug resistance: role of the fibroblast niche.pdf

Front.Bio1.2014,9(2):114—126 D0Il0.1O07/sl1515-0l4一l300—8 Primingcancercellsfordrugresistance:roleofthefibroblast niche WeiBinFANG,MinYAO,NikkiCHENG(函) DepartmentofPathologyandLaboratoryMedicine,UniversityofKansasMedicalCente~KansasCity,KS66160,USA ◎HigherEducationPressandSpringer-VerlagBerlinHeidelberg2014 Abstract Conventionalandtargetedchemotherapiesremainintegralstrategiestotreatsolidtumors.Despitethelarge numberofanti.cancerdrugsavailable,chemotherapydoesnotcompletelyeradicatedisease.Diseaserecurrenceandthe growth ofdrugresistanttumorsremain significantproblemsin anti—cancer

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