急性冠脉综合征GDF-15水平的变化和临床意义.docVIP

精品论文 参考文献 急性冠脉综合征GDF-15水平的变化和临床意义 黄桂锋 (汕头市潮阳区大峰医院 广东汕头 515154) 【摘要】目的：初步探讨GDF-15在急性冠脉综合征(acute coronary syndrome ACS)患者中的表达规律及临床意义。方法：分别测定50名稳定型心绞痛(stable angina pectoris SAP)患者，50名ACS患者和30名对照患者血清生长分化因子-15(growth-differentiation factor-15 GDF-15)的浓度，计算其Gensini积分以及随访各组患者30天内的主要不良心血管事件(MACE)。结果：冠心病患者的GDF-15水平较非冠心病患者明显升高，且ACS组GDF-15水平升高较SAP组更显著，差异均有统计学意义(P值均＜0.05)；GDF-15与Gensini积分不存在相关性(Pgt;0.05)；Logistic多因素回归分析发现GDF-15与30天内MACE关系密切(OR值为1.167)。结论：研究提示GDF-15浓度可能在ACS早期诊断、指导治疗和评估短期预后上有一定的临床意义。 【关键词】急性冠脉综合征 GDF-15 Gensini积分 预后 【中图分类号】R54 【文献标识码】A 【文章编号】2095-1752（2014）18-0061-03 The Change in GDF-15 Level in Patients with Acute Coronary Syndrome and its Clinical Significance Huang Gui-Feng Dafeng hospital, Chaoyang District, Shantou, Guangdong, China 515154 【Abstract】Objective: The purpose of this study is to investigate the expression pattern of GDF-15 in patients with acute coronary syndrome and to assess its significance in clinic. Methods: 50 patients with stable angina pectoris (SAP) and 50 patients with acute coronary syndrome (ACS) were enrolled as subjects and 30 individuals without ACS were served as control group. The level of serum growth-differentiation factor-15 (GDF-15) of each patient from SAP group, ACS group and control group was measured and the Gensini scores were calculated. The major adverse cardiovascular events (MACE) among patients from each group within 30 days were recorded during the clinical follow-up. Results: The GDF-15 level of patients with coronary artery disease (CAD) was higher than that of patients without CAD. Especially, the level of GDF-15 in ACS group was significantly higher than that in SAP group. The difference in the two comparisons had significance in statistics (Plt;0.05). However, no correlation was observed between GDF-15 level and Gensini score. The result of multiple logistic regression analysis showed that the le