急性骨创伤早期应激性高血糖患者超敏C反应蛋白与血管内皮功能的相关性.docVIP

精品论文 参考文献 急性骨创伤早期应激性高血糖患者超敏C反应蛋白与血管内皮功能的相关性 徐江1 李晓芸2 刘亚梅1 刘俊孚1 　　（1.秦皇岛市骨科医院 河北 秦皇岛 066000；2.秦皇岛市第三医院 河北 秦皇岛 066000） 　　【摘 要】目的：观察急性骨创伤早期应激性高血糖患者超敏C反应蛋白(hs-CRP)与血管内皮功能的水平,探讨其对血管内皮功能的影响。方法：根据入院时血糖检测结果,选择就诊我院的急性骨创伤早期应激性高血糖组42例，同时选择急性骨创伤早期血糖正常组30例,检测患者的肱动脉内皮依赖性舒张功能(FMD)、空腹血糖、空腹胰岛素、高敏C反应蛋白、血脂。结果与血糖正常组比较, 应激性高血糖组的空腹血糖、hs-CRP明显升高(Plt;0.05),肱动脉FMD明显降低[(4.41plusmn;0.59)%vs(11.27plusmn;0.51)%,Plt;0.01]。结论：急性骨创伤早期应激性高血糖患者存在明显的内皮功能紊乱，超敏C反应蛋白含量与血管内皮功能不全相关。 　　【关键词】应激性高血糖；超敏C反应蛋白；血管内皮功能 　　【中图分类号】R587.1;R587.2 【文献标识码】A 【文章编号】1004-6194（2015）01-0297-01 　　The correlation between hypersensitive C-reactive protein and vascular endothelial function in patients with stress hyperglycemia during early acute bone trauma 　　Xu Jiang1, Li Xiaoyun2, Liu Yamei1, Liu Junfu1. 　　Orthopedics Hospital of Qinhuangdao1, 066000, The Third Hospital of Qinhuangdao2, 066000 　　【Abstract】Objective: To observe the hypersensitive C-reactive protein (hs-CRP) and vascular endothelial function level and to investigate the effect of hs-CRP on vascular endothelial function in patients with stress hyperglycemia during early acute bone trauma. Methods: 42 cases of acute bone trauma with stress hyperglycemia and 30 cases of acute bone trauma with normal blood glucose were selected as study subjects according to blood glucose test results. Endothelium-dependent vasodilation (FMD), fasting blood-glucose, fasting insulin, hs-CRP and blood lipid were detected. Results: The fasting blood-glucose and hs-CRP of stress hyperglycemia group were significantly higher than normal blood glucose group (Plt;0.05) while FMD was lower compared to normal blood glucose group ((4.41plusmn;0.59)%vs(11.27plusmn;0.51)%,Plt;0.01). Conclusion: There is obvious endothelial dysfunction in patients with stress hyperglycemia during early acute bone trauma. hs-CRP is not entirely relevant to endothelial dysfunction. 　　【Key words】stress hyperglycemia; hypersensitive C-reactive protein (hs-CRP); vascular endothelial function 　　应激性