托吡酯和丙戊酸钠预防偏头痛发作的疗效及安全性比较.docVIP

精品论文 参考文献 托吡酯和丙戊酸钠预防偏头痛发作的疗效及安全性比较 李洪渊 　　（四川绵阳三台县中医院 四川绵阳 621100） 　　【摘要】目的：比较托吡酯和丙戊酸钠预防偏头痛发作的疗效及安全性。方法：本研究于2015年1月～2015年12月将收治的84例偏头痛患者按照数字表法随机分为研究组和对照组，每组各42例，其中对照组给予丙戊酸钠治疗，而研究组给予托吡酯治疗，比较两组患者的临床治疗效果及不良反应发生情况。结果：研究组和对照组治疗后头痛发作频率、头痛天数及头痛程度均较本组治疗前明显改善，而研究组的改善程度则明显优于对照组，且差异具有统计学意义（t=3.45、3.92、3.28，Plt;0.05）。研究组患者治疗后平均头痛频率减少和头痛减轻程度均较对照组明显改善，且差异具有统计学意义（t=3.19、3.68，Plt;0.05）。研究组患者中发生头晕3例，乏力2例，食欲减退2例；对照组患者中发生头晕2例，乏力1例，恶心呕吐2例，经统计学分析发现两组患者的不良反应发生率比较无明显差异（chi;2=0.98，Pgt;0.05）。结论：托吡酯和丙戊酸钠均可以有效预防偏头痛发作，但是相比较而言，托吡酯在减少头痛频率和头痛程度方面明显优于丙戊酸钠，且不良反应少，值得临床推广使用。 　　【关键词】托吡酯；丙戊酸钠；偏头痛 　　【中图分类号】R453 【文献标识码】A 【文章编号】1007-8231（2016）04-0133-02 　　 Comparison of efficacy and safety of topiramate and sodium valproate in migraine prophylaxis 　　【Abstract】Objective To compare the efficacy and safety of topiramate and sodium valproate in prevention of migraine. Methods From January 2015 to December 2015, 84 cases of migraine patients were randomly divided into study group and control groupaccording to the digital table method, 42 cases in each group.The control group was treated with sodium valproate andthe study group was treated with topiramate.Clinical curative effect and adverse reaction were compared between the two groups. Results After treatment, headache attack frequency, headache days and degree of headache in study group and control group were compared with those before treatment had improved significantly, and degree of improvement in the study group was obviously better than that of the control group, and the difference was statistically significant (t=3.45, 3.92, 3.28, Plt;0.05). The average headache frequency and headache relief in the study group were significantly improved compared with the control group, and the difference was statistically significant (t=3.19, 3.68, Plt;0.05). Patients in the study group in the occurrence of dizziness (3 cases), weakness in 2 cases, loss of appetite (2 cases), control group patients occurred in 2 cases of