Talin and kindlin： the one-two punch in integrin activation.pdfVIP

Front．Med．2014，8(1)：6-16 DOI10．1007／sl1684—014—0317—3 REVIEW Talinandkindlin：theone●． opunc0I1IinI●nte‘grl●nact。0ivat。0ion FengYe(囟)，AdamK．Snider,MarkH．Ginsberg(函) DepartmentofMedicine,UniversityofCalfiornia．SanDiego．LaJottaCA92093．USA ◎HigherEducationPressandSpringer-VerlagBerlinHeidelberg2014 Abstract Propercell-cellandcell-matrixcontactsmediatedbyintegrin adhesion receptorsareimportantfor development，immune response，hemostasis and wound healing．Integrins pass trans-membrane signals bidirectionallythroughthei