探讨盐酸贝那普利联合螺内酯治疗糖尿病心脏病心力衰竭的临床效果.docVIP

精品论文 参考文献 探讨盐酸贝那普利联合螺内酯治疗糖尿病心脏病心力衰竭的临床效果 望奎县人民医院 152100 【摘 要】目的：研究分析盐酸贝那普利联合螺内酯治疗糖尿病心脏病心力衰竭的有效性和安全性。方法：此次研究的对象是选择我院2012年9月—2013年9月收治的76例糖尿病心脏病心力衰竭患者，将其临床资料进行回顾性分析，并随机分为观察组和对照组各38人，对照组使用常规抗心衰治疗，观察组使用盐酸贝那普利联合螺内酯组进行治疗。观察比较2组患者治疗前、后左室舒张末期内径（LVEDd）、左室射血分数（LVEF）、心率和心功能疗效改善情况和不良反应。结果：治疗3个月后，观察组治疗后各项指标改善显著优于对照组，2组比较差异有统计学意义（Plt;0.05）；治疗中，2组均有少数患者出现轻微不良反应。结论：盐酸贝那普利联合螺内酯可有效改善糖尿病心脏病心力衰竭患者的心功能，疗效确切，安全性好，可在临床推广应用。 【关键词】盐酸贝那普利；螺内酯；心力衰竭；疗效；安全性 [Abstract] Objective：To study and analyze the benazepril hydrochloride combined with spironolactone in the treatment of diabetic heart failure is effective and safe.Methods：the object of this study is in our hospital in September 2012 - 2013 September were 76 cases of diabetic heart disease heart failure patients，the clinical data were retrospectively analyzed and randomly divided into observation group and control group（n = 38），the control group using conventional anti heart failure treatment，observation group with benazepril hydrochloride combined with spironolactone group and control group.Observe the 2 groups of patients before and after treatment，left ventricular end diastolic diameter（LVEDd），left ventricular ejection fraction（LVEF），heart rate and cardiac function improvement and adverse reactions.Results：3 months after treatment，the observation group after treatment，the improvement was significantly better than the control group，there were significant differences between the 2 groups（Plt;0.05）；treatment，2 groups had a small number of patients with mild adverse reactions.Conclusion：Combined Benazepril and spironolactone can effectively improve diabetic heart disease in patients with heart failure of heart function，the curative effect is accurate，safety，in clinical application. [Key words] Benner Pury hydrochloride；spironolactone；congestive heart failure；curative effect；safety 糖尿病心脏病心力衰竭是糖尿病患者致死的主要原因之一，病情多比较严重，预后比较差，病死率较高[1]。盐酸贝那普利为血管转换酶抑制药，具有降血压和治疗心力衰竭的作用，螺内酯为抗醛固酮制剂，在心力衰竭治疗中有较长的应用历史[2]。许多大规模的临床试验均证实盐酸贝那普利与螺内酯联合使用，能降低心力衰竭