多种血管活性物质与细胞膜离子转运与高血压的相互关系.docVIP

多种血管活性物质与细胞膜离子转运与高血压的相互关系 多种血管活性物质与细胞膜离子转运与高血压的相互关系 2011-06-15 商黔惠　王丕荣　李琮辉　马淑玉　陈剑玲　文雍 　　【摘要】　目的　探讨血管活性物质与细胞膜离子转运的关系及其在高血压病（EH）发病中的作用。方法　观察107例EH患者和30例正常人血浆多种血管活性物质、淋巴细胞离子泵和阳离子变化，并对血压与13个相关预选因子进行逐步回归分析。结果　EH患者血浆内皮素、血管紧张素Ⅱ、内源性洋地黄物质、去甲肾上腺素和心钠素增高，它们彼此相关并与淋巴细胞钠泵和钙泵活性下降、Na+和Ca2+浓度升高相关，其中血管紧张素Ⅱ、去甲肾上腺素、心钠素、细胞钠泵和Na+与血压之间有独立的相关关系。结论　体循环中多种血管活性物质含量改变和相互作用与细胞膜离子转运缺陷有密切的内在关系，并可能在EH的发病过程中起协同和促进作用。 　　【关键词】　高血压　　肽类　　腺苷三磷酸酶 Plasma vasoactive substances and cell cation transport in patients with essential hypertension　　Shang Qianhui, Wang Pirong, Li Conghui, et al. First Affiliated Hospital, Zunyi Medical College, Zunyi 563003 　　【Abstract】　Objective　To sutdy the effect of vasoactive substances and cell cation transport function in the pathogenesis of essential hypertension (EH). Methods　Plasma endothelin (ET), angiotensin Ⅱ (AngⅡ), endogenous digitalis-like substances (EDLS), norepinephrine (NE) and atrial natriuretic peptide (ANP) were determined, lymphocytic membraneion pumps and cations were also measured in 107 EH patients and 30 healthy subjects. Multiple stepewise regression analysis was computed using blood pressure as dependent variable and 13 parameters as independent variables. Results　It was found that in EH patients, ET, AngⅡ, EDLS, NE and ANP were all increased and correlated with each other. The increase of ET, AngⅡ, EDLS, NE and ANP were closely related to the decrease of Na+-K+-ATPase and Ca2+-ATPase activities and the enhance of Na+ and Ca2+. The regression equation revealed that AngⅡ, NE, ANP, Na+-K+-ATPase activity and Na+ were the independent factors affecting blood pressure in EH patients. Conclusion　The changes of vasoactive substances levels in the circulation and cation transport function in the cell, or the interaction among them may play important roles in the pathogenic mechanisms of EH. 　　【Key words】　hypertension　　peptides　　adenosinetriphosphatase 　　已知血管活性物质含量异常、细胞膜离子转运缺陷与高血压病（EH）发病密切相关［1］。但迄今未明确多种血管活性物质与细胞膜离子转运之间的相互关系及其在EH发病中的作用。本研究旨在从人类整体水平，综合观察它们