小剂量阿司匹林合并华法林对心脏瓣膜置换术后患者的抗栓效果.docVIP

小剂量阿司匹林合并华法林对心脏瓣膜置换术后患者的抗栓效果 方汉军 李锋华 许诚 延安大学咸阳医院心脏外科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 探讨小剂量阿司匹林合并华法林对心脏瓣膜置换术后患者的抗栓效果。方法 以在我院2014年1月至2016年12月间接受心脏瓣膜置换术治疗的100例患者作为研究对象, 根据不同的抗栓治疗方法, 将其分为观察组 (n=52) 与对照组 (n=48) 。其中对照组患者使用华法林进行治疗, 而观察组患者联合使用华法林与小剂量阿司匹林进行治疗。观察并比较两组患者的抗栓效果。结果 观察组患者血栓栓塞发生率、抗凝相关出血发生率明显低于对照组 (P0.05) 。结论 在华法林基础上, 给予心脏瓣膜置换术患者小剂量阿司匹林, 能显著减少血栓形成及栓塞的发生, 而且安全有效。 关键词： 小剂量; 阿司匹林; 华法林; 心脏瓣膜置换术; 抗栓效果; 收稿日期：2017-04-20 Study on the Effect of Low dose Aspirin Merger of Warfarin on Antithrombotic in Patients after Cardiac Valve Replacement FANG Han-jun LI Feng-hua XU Cheng Department of cardiac surgery, Xianyang hospital, Yanan University; Abstract： Objective To study on the effect of low dose aspirin merger of warfarin on antithrombotic in patients after cardiac valve replacement. Methods The 100 patients treated with cardiac valve replacement in our hospital were considered as study objects and the clinical data were analyzed retrospectively. They were divided into observation group ( n = 52) and control group ( n = 48) according to different antithrombotic treatment. The patients were treated with warfarin in the control group, while the patients were treated with low dose aspirin based on warfarin in the observation group. The treatment effects were observed and compared.Results The incidence of thrombosis and Incidence of related bleeding in the observation group were significantly lower than that in the control group ( P 0. 05) . Conclusion On the basis of warfarin, small dose aspirin is used for the patients with cardiac valve replacement, and it can significantly reduce thrombosis and embolism it is safe. Keyword： Low dose; Aspirin; Warfarin; Cardiac valve replacement; Antithrombotic effect; Received： 2017-04-20 心脏瓣膜置换术后患者为了防止血栓形成, 并需终身接受抗栓治疗, 否则会发生血栓栓塞并发症, 严重威胁到患者的生命安全[1]。在抗栓治疗过程中, 口服华法林在临床上使用较为广泛。然而, 该药物个体差异较大, 且自身治存在较窄安全范围, 极易发生血栓形成 (抗凝不足) 或出血 (抗凝过量) 等并发症[2]。针对华法林的抗凝强度, 目前国内临床上还尚未达到一致标准。因此, 合理并正确进行