新型创伤失血性休克后腹腔高压症模型及其应用研究.docVIP

精品论文 参考文献 新型创伤失血性休克后腹腔高压症模型及其应用研究 刘春 刘红丽 赵晓亮 于彩霞 高福春 宋慧芳通讯作者 　　河北省唐山市滦县人民医院 河北唐山 063700 　　【摘 要】目的：探讨新型创伤性失血性休克后腹腔高压症模型的建立和临床应用价值。方法：选取实验室的SD大鼠28只随机将其分成2组，A组（14只）：经股动脉放血致失血性休克，维持MAP40mmHg，60min后行门静脉恒定缩窄，大鼠腹部未放置束缚设备；B组：进行静脉恒定缩窄，60min后动脉放血致失血性休克，维持MAP40mmHg2h，然后在腹部安装束缚装置。同时选取28只SD大鼠随机分成两组，即C组（14只）输入平衡盐溶液（LR），D组输入高渗盐溶液(HS)，对比两组患者的复苏情况。结果：A组大鼠全部死亡，成功率为0；B组大鼠92.86%；C组成功率为85.71%，D组成功率为21.43%。结论：在制作继发性IAH试验模型时使用恒定门静脉窄缩，静脉放血MAP在40mmHg维持2h，然后使用LR液体复苏方式成功率较高。 　　【关键词】创伤失血性休克；液体复苏；腹腔高压症 　　【中图分类号】R605.971 【文献标识码】B 【文章编号】1674-8999（2015）8-0257-02 　　Model of traumatic hemorrhagic shock after abdominal hypertension model and its application 　　 Liu Chun Liu Hongli Zhao Xiaoliang Yu Caixia Gao Fuchun Song Huifang 　　Luanxian peoples Hospital of Hebei Province, Tangshan City Luanxian 063700 　　【Abstract】Objective: To study the model of traumatic hemorrhagic shock after the establishment of intra-abdominal hypertension model and clinical application value. Methods: laboratory 28 SD rats were randomly divided into 2 groups, group A (14): the femoral artery bleeding caused by hemorrhagic shock, maintaining MAP40mmHg, 60min through portal vein coarctation ratsabdominal constant, without placing restraint devices; B group: constant venous constriction,60min artery bleeding caused by hemorrhagic shock, maintain MAP40mmHg2h, and then in thebelly mounted restraint device. At the same time, a total of 28 SD rats were randomly divided into two groups, group C (14) input balanced salt solution (LR), D group of hypertonic saline solution(HS), the recovery of the two groups were compared. Results: the rats in group A were all died,the success rate was 0; 92.86% rats in the B group; C group the success rate was 85.71% in group D, the success rate is 21.43%. Conclusion: the use of constant gate in the production ofsecondary IAH test model of venous narrowing, venous blood MAP maintenance of 2h in40mmHg, and then use the LR fluid resuscitation success rate higher. 　　【keyword】traumatic hemo