糖痹宁联合甲钴胺治疗糖尿病周围神经病变的临床观察Clinical observation of Tangbi Ning combined with Methylcobalamin in treatment of diabetic peripheral neuropathy.pdfVIP

提 要 研究目的：观察糖痹宁联合西药治疗糖尿病周围神经病变的临床疗效以及相对于 单纯西药治疗的优势。 研究方法：采用前瞻性随机对照的方法，将符合诊断标准的 60 例糖尿病周围神 经病变患者，随机分为治疗组与对照组，每组 30 例。在糖尿病基础降糖治疗(西医基 础治疗）的基础上，治疗组予（口服）糖痹宁联合甲钴胺注射液 500ug 皮下注射，对 照组予甲钴胺注射液 500ug 皮下注射，治疗观察 8 周，将治疗前后的临床症状评分及 神经传导速度进行统计学分析。 研究结果：两组患者治疗后在（中医症候评分）症状及神经传导速度两方面都得 到明显改善，其中治疗组总有效率 83.33%，对照组总有效率 63.33% 。糖痹宁联合西 药治疗在患者症状改善、神经传导速度方面明显优于对照组(P0.05) 。 结论：糖痹宁联合甲钴胺在治疗气阴两虚兼血瘀型糖尿病周围神经病变有良好的 疗效，且安全性良好，提供了中医药治疗周围神经病变的新思路。 关键词：糖尿病周围神经病变；糖痹宁；甲钴胺注射液；中西医结合疗法 The clinical Research of Tang bingning combined with cobalt ammonium injection treating Diabetic Peripheral Neuropathy Specialty: Traditional Chinese Internal Medicine Author: Wang ting ting Tutor: Professor Zhang Dexian ABSTRACT Purpose: To observe the clinical therapeutic effect of Tang bining combined with cobalt ammonium treating the diabetic peripheral neuropathy and relative advantage of simple western medicine. Method: The prospective randomized method would be adapted in dividing sixty DPN patients into two groups, one is treatment group (Tang bining combined with cobalt ammonium injection 500ug each time), the other is control group(cobalt ammonium injection 500ug each time), each group has thirty patients who correspond with the diagnosis standard. Then compared with clinical symptom score and nerve conduction velocity of both sides after eight weeks treatment with statistical method. Result: Two groups of patients in clinical symptoms and nerve conduction velocity have improved . The total effective rate is 63.33% in treatment group,while its 83.33% in control group. Tang bining combined with western medicine is much better than the control group in the clinical symptom and the nerve