曲美他嗪对酒精性心肌病心肌酶学的影响.docVIP

精品论文 参考文献 曲美他嗪对酒精性心肌病心肌酶学的影响 山东省威海市市立二院心内科 264200 摘要：目的：探讨酒精性心肌病的血清酶学变化及曲美他嗪对其心肌酶学的影响。方法：将符合酒精性心肌病的患者随机分成两组，两组病人均同意戒酒，其中A组（对照组）患者在戒酒的基础上给予患者酒精性心肌病的常规治疗及对症治疗，另B组（曲美他嗪组）患者在戒酒、常规治疗、对症治疗，同时给予曲美他嗪药物治疗。然后对两组病人在用药前及用药前后阶段进行酶学分析（心肌肌钙蛋白T（cTnT）及血浆超氧话务歧化酶（SOD）丙二醛（MDA）），最后收集数据，并对两组病人的酶学指标数据进行统计学分析。结果：1.A组（对照组）与B组（曲美他嗪组）相比，在任何治疗前、两组的cTnT及SOD、MDA指标相比无差别显著性，（Pgt;0.05）2.用药后4周，两组的cTnT及SOD、MDA指标与治疗前前相比有差别显著性，（P＜0.05）3.用药后4周，两组组间相比MDA T（cTnT）对照组与曲美他嗪组相比无显著差异（Pgt;0.05）；SOD对照 组与曲美他嗪组相比有差别显著性，（P＜0.05）4.A组（对照组）与B组（曲美他嗪组）相比，用药后16周，两组的cTnT及SOD、MDA指标相比无差别显著性，（Pgt;0.05）。结论：反复大量饮酒，酒精毒性代谢产物乙醛作为一种直接细胞毒性物质致心肌细胞损伤，同时引发氧自由基代谢失衡、脂质过氧化过程。通过戒酒、常规治疗、及曲美他嗪治疗可明显改善患者各项酶学指标，酶学变化示曲美他嗪有改善自由基代谢作用，对心肌有保护及修复作用。 关键词：酒精性心肌病；曲美他嗪；超氧化物歧化酶；丙二醛；肌钙蛋白 [Abstract]Objective：To investigate the changes of serum enzymes and QuMei alcoholic cardiomyopathy effect of trimetazidine on the myocardial enzyme.Methods：with alcoholic cardiomyopathy were randomly divided into two groups，the patients in the two groups have agreed to stop drinking，which in group A（control group）in patients with on the basis of abstinence give patients with alcoholic cardiomyopathy routine treatment and symptomatic treatment，the other group B（Qumei trimetazidine group）patients in drinking，conventional treatment，symptomatic treatment，while giving trimetazidine medicine treatment.Then the two groups of patients before and after before the treatment and after the treatment of enzymatic analysis（cardiac troponin T（cTnT）and plasma superoxide traffic dismutase（SOD）and malondialdehyde（MDA）.Finally，collect data，and of two groups of patients the enzyme indexes of data for statistical analysis.Results：compared to the a group（control group）and group B（trimetazidine group），before any treatment，two groups of cTnT and SOD，MDA in compared no significant difference（P gt; 0.05）.After treatment for 4 weeks，two groups of cTnT and the activity of SOD，MDA and the treatment of the former compared to a significant difference，（P lt; 0.05）.After treatment for 4 weeks，two grou