第22章治疗呼吸系统疾病药物.ppt

主要呼吸系统疾病的临床用药 平 喘 药 Magnitude of the Problem 15- 20 million asthmatics in India. A recent study conducted in Delhi established asthma prevalence to be 12% in schoolchildren. Significant cause of school/work absence. Health care expenditures very high. Morbidity and mortality are on the rise. JAPI 2002; Vol 50: 462. 哮喘发病 机制示意图 炎症细胞、 炎症介质、细胞因子 的相互作用 遗传因素 环境因素 神经调节 失衡以及气道平滑 肌功能异常 气道炎症 气道高反应性 支气管哮喘 平滑肌痉挛 The Underlying Mechanism INFLAMMATION Risk Factors (for development of asthma) AirwayHyperresponsiveness Airflow Limitation Symptoms- (shortness of breath, cough, wheeze) Risk Factors(fo