泰兴市3～5岁儿童乙肝疫苗免疫效果研究.docVIP

精品论文 参考文献 泰兴市3～5岁儿童乙肝疫苗免疫效果研究 （泰兴市疾病预防控制中心 江苏 泰兴 225400） 【摘要】目的：了解我市2009年～2011年出生（3～5岁）的常住儿童乙肝表面抗原携带情况和乙肝疫苗免疫效果，探讨乙肝疫苗加强免疫可行性。方法：随机抽取我市两个乡镇2009年～2011年出生（3～5岁）的规范完成乙肝全程免疫程序并未加强接种的1451名儿童用ELISA法进行乙肝表面抗原（HBsAg）和乙肝表面抗体（HBsAb）检测，结果:发现HBsAg阳性6例，阳性率0.41%；HBsAb阳性者829例，阳性率57.13%，男女差异无统计学意义（chi;2=1.31，P＞0.05），各年龄组间HBsAb阳性率有统计学意义（chi;2=56.09，P＜0.01），HBsAb阳性率随着年龄的增长而呈逐年下降趋势（chi;2趋势性检验=55.56，P＜0.01）。结论：经正规免疫程序免疫的儿童乙肝病毒携带率很低；乙肝疫苗免疫效果会随着免疫年限延长而降低，建议在我市推行4岁及以上儿童乙肝疫苗加强免疫策略。 【关键词】 儿童；乙肝疫苗；免疫效果 【中图分类号】R72 【文献标识码】A 【文章编号】2095-1752（2015）35-0047-02 Immune Effect of vaccine Taixing 3-5 year-old children with hepatitis B QIan Xia, LI Youjia, Wu Shuhua, Hanzhi Jing 【Abstract】Objective Understanding the city in 2009 - 2011 was born (3-5 years) resident children carrying hepatitis B surface antigen and hepatitis B vaccine effect situation, To investigate the feasibility of hepatitis B vaccine booster. Methods Randomly selected from the citys two towns in 2009 - 2011 was born (3-5 years) specification does not complete the hepatitis B immunization program throughout 1451 to strengthen the vaccination of children with ELISA for hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (HBsAb ) testing positive for HBsAg and found six cases, the positive rate 0.41%; HBsAb positive in 829 cases, the positive rate 57.13%, no significant difference between men and women (x2 = 1.31, Pgt; 0.05), among all age groups HBsAb positive rate statistically significant (x2 = 56.09, Plt;0.01), HBsAb positive rate with age and declining trend (x2 trend test = 55.56, P lt;0.01). Conclusion The regular immunization schedule for children of HBV immunization rate is very low; the effect of hepatitis B vaccine will be immunized with extended service life and lower, recommended the introduction of 4 years and older children in the city of hepatitis B vaccine booster policies. 【Key words】Children; hepatitis B vaccine; Immune2002年正式纳入免费计划免疫。2014年，随机抽取