“抛砖引玉”-谈谈本人申报课题的体会-2011(二院).ppt

哈医大国家自然科学基金申请喜获丰收;Chang-Qing XU Dept. Pathophysiology, HMU;明年基金申请变化;; ;;面上项目; ;;;;;;;;;;申报注意事项 ;申报注意事项 ;管理体会;;科研、课题和人才的关系;一、如何才能做好科研？;稳定的科研方向;走出国门见世面，学来真经报祖国;Study contents and results; （2）first time discovered that acivition of CaSR could induce intracellular Ca by G-protein-PLC-IP3 pathway, which is a mechanism for calcium overload. ;（3）First revealed expression rule and critical role of CaSR in cardiac I/R injury and apoptosis through activating MAPKs ( p38, JNK,ERK) - cytochrome c –caspase-3 pathway and Fas receptor death pathway.;（4）first time found that the change of CaSR activity mediated by PKCεis involved in cardiac protection induced by ischemic postconditioning. ;（5）first discovered that CaSR expression is increased in cardiac hypertrophy, which signal is involved in CaN and PKC pathways。;（6）first revealed that increase of CaSR expression in artherosclerosis rat induce increased sensitivity to AMI; (7) first demonstrated that polyamine homeostasis is very important for myocardium，and spermine in higher or lower concentration could induce myocardial damage, as a double edged sword. ;(8) first time demonstrated that exogenous spermine with low concentration possese protection for cardiac ischemia/ reperfusion injury.;(9) first time demonstrated existance of CaSR functional expression in pulmonary artery and PAMSC. ;(10) first time demonstrated CaSR Mediates Hypoxia-InducedProliferation of Rat PASM CellsThrough MEK1?ERK1,2 and PI3K Pathways;(11) first time demonstrated The functional expression of CaSR in the differentiated THP-1 cells ;SCI(28); PubMed(24); 大鼠心肌钙敏感受体的生物活性及其在心肌缺血/再灌注损伤中作用 黑龙江省自然科学二等奖 (2008);教材建设 ; Academic reports; “The investigation progress of CaSR in cardiovascular system”； “Calcium sensing receptor induced cardiomyocyte apoptosis through ER pathway in hypoxia/ reoxygenation” ;http://m.pu.ru/index.php?option=com_contenttask=viewid=132Itemid=118;Zhao Yajun Sun Yihua Han Liping;Ph.D candida