狼疮性肾炎91例临床与病理分析.docVIP

精品论文 参考文献 狼疮性肾炎91例临床与病理分析 王尚龙（河南省信阳市固始县人民医院 465200） 【摘要】目的 探讨狼疮性肾炎(LN)的病理与临床分析，了解病理改变与临床表现之间的联系。方法 回顾性分析我科91例LN患者的临床病理分析。结果 LN的肾脏病理改变91例患难与共者中以Ⅳ型最多48例(52.7%)，其次是Ⅲ型，为24例(26.4%)，对少见分别为I型3例(3.3%)，Ⅱ型9例(9.9%)，V型7例(7.7%) (其中3例合并Ⅲ型、3例合并Ⅲ型为Ⅳ+V、Ⅳ+V)，其结果显示Ⅱ型、Ⅲ型、Ⅳ型LN样改变，其均诊断为LN 。91例中大部分患者出现多种临床表现，常见的有皮疹、浮肿、蛋白尿、贫血、高血压、心血管疾病、关节炎、发热、等，91例LN患者中以皮疹为首发临床表现者60例，占65.9%。后全部是肾脏损害。结论 狼疮性肾炎的病理类型与临床表现、实验室检查起着非常重要的作用；肾活检对判断疾病活动性，指导治疗与评估预后有重要意义。 【关键词】狼疮性肾炎 临床病理 分析 【中图分类号】R692.3【文献标识码】A【文章编号】1672-5085（2012）17-0085-02 【Abstract】Objective: To investigate the lupus nephritis ( LN ) in the pathological and clinical analysis of pathological changes and clinical manifestations, understanding the link between. Methods: retrospectively analyzed in 91 cases of LN patients clinical pathology analysis. Results: the LN renal pathological changes in 91 cases with type IV up come with sb. In 48 cases (52.7%), followed by the type III, 24 cases (26.4%), on the rare were type I in 3 cases (3.3%), type 9 (9.9%), type V in 7 cases (7.7%) (of which 3 cases of combined type, 3 cases with type III to IV + V + V, IV), the results showed that type II, III, IV LN changes, which were diagnosed as LN. In 91 cases there for most of the patients in a variety of clinical manifestations, there is a common rash, edema, proteinuria, anemia, hypertension, cardiovascular diseases, arthritis, fever, and, in 91 cases of LN with skin lesions as the first clinical manifestation in 60 cases, accounting for 65.9% of. After all the kidney damage. Conclusion: the pathology of lupus nephritis types and clinical manifestations, laboratory examination plays a very important role; renal biopsy to determine the activity of the disease, treatment and evaluation of prognosis. 【Key words】 lupus nephritis Clinical Pathology analysis 系统性红斑狼疮(SLE)是可损害各个系统和器官的自身免疫性疾病，临床上以肾脏损害最多见，临床上有狼疮性肾炎(LN)表现者高达70%左右。LN是继发性肾脏病导致终末期肾衰竭的常见病因之一，可达70%—90%。肾衰竭是狼疮性肾炎(LN)的常见死因。我科对91例LN患者的病理分型与临床表现、病理分型与相关实验室检查、病理分型与SLE临床活动性及LN病理活动性的关系进行分析，以确定疾病的严重