甘露醇配合甘油果糖在脑转移瘤中的脱水效果比较.docVIP

精品论文 参考文献 甘露醇配合甘油果糖在脑转移瘤中的脱水效果比较 潘峰 彭青松 杨光荣 　　（重庆市綦江区人民医院 重庆 401420） 　　【摘要】 目的：探讨甘露醇配合甘油果糖在治疗脑转移瘤中的脱水效果，并评估其临床价值。方法：选取我科2014年9月至2015年9月收治的60例脑转移瘤患者，随机分为对照组和观察组，每组均为30例，对照组采用20%甘露醇125ml静脉滴注，观察组则采用20%的甘露醇125ml配合250ml甘油果糖注射液交替静脉滴注，比较两种药物及给药方法脱水效果。结果：经两种方法治疗后，观察组患者的治疗有效率明显高于对照组，并经CT结果显示，观察组的脑水肿缓解程度明显优于对照组，差异均符合统计学意义(Plt;0.05)，同时观察组患者发生肾功能损伤的不良反应例数明显低于对照组，差异具有统计学意义（Plt;0.05)。结论：在脑转移瘤的脱水治疗中，甘露醇配合甘油果糖的脱水效果较好，能有效改善患者的临床症状，降低颅内肿瘤引起的脑水肿程度，且不良反应发生率更低。 　　【关键词】 甘露醇；甘油果糖；脑转移瘤；脱水 　　【中图分类号】R742 【文献标识码】A 【文章编号】2095-1752（2016）20-0060-02 　　The dehydration effect comparison of mannitol with glycerol fructose in brain metastatic tumor 　　Pan Feng, Peng Qingsong, Yang Guangrong. The Peoples Hospital of Qijiang District, Chongqing City, Chongqing 401420, China 　　【Abstract】Objective Explore the mannitol with glycerol fructose dehydration effect in the treatment of brain metastases and evaluate its clinical value. Methods Choose between September 2014 and September 2014 were 60 cases of patients with brain metastases, randomly divided into control group and observation group, 30 cases in each group. The control group using 20% mannitol 125 ml intravenous drip. Observation group using 20% mannitol 125 m, with 250 ml of glycerol and fructose injection and intravenous drip alternately. Results Observation group of patients treatment efficient and brain edema relieved degree, significantly higher than the control group. Renal injury of adverse reaction cases, observation group significantly lower than the control group. Statistically significant difference (P lt; 0.05). Conclusions In the dehydration treatment of brain metastases, mannitol with glycerin fructose, dehydration effect is good, can effectively improve the patients clinical symptoms, reduce degree of cerebral edema and intracranial tumor and a lower incidence of adverse reactions. 　　【Key words】Mannitol; Glycerol fructose; Brain metastases tumor; Dehydration 　　脑转移瘤在临床上是指由患者身体其他部位的原发肿瘤转移至颅脑，