盐酸羟考酮控释片治疗癌痛疗效观察.docVIP

精品论文 参考文献 盐酸羟考酮控释片治疗癌痛疗效观察 孙祥1 孟曼2 黄梦芹2 （1合肥市第一人民医院血液肿瘤科 230061） （2合肥市第二人民医院肿瘤内科 230011） 【摘要】目的 观察盐酸羟考酮控释片治疗中、重度癌痛的临床效果、不良反应及患者生活质量的改善情况。方法 31例中、重度疼痛患者给予盐酸羟考酮控释片镇痛治疗，根据疼痛的缓解程度来调整剂量。每位患者至少治疗15天，同时进行疼痛强度、生活质量评分及不良反应观察。结果 总的疼痛缓解率为93.5%，其中完全缓解为45.2%明显缓解为41.9%，中度缓解为6.5%，患者生活质量明显提高，不良反应少且轻微。结论 盐酸羟考酮控释片治疗中、重度癌性疼痛疗效显著，不良反应较少，能显著改善癌症患者的生活质量。 【关键词】肿瘤 疼痛 奥施康定 【中图分类号】R730.53 【文献标识码】A 【文章编号】2095-1752（2012）13-0383-01 Clinical Application of Oxycodone Hydrochloride Controlled ndash; Release Tablets in the Treatment of Terminal Cancer Pain Sun Xiang meng Mman Huang Mengqin Department of Oncology, Hefei No.1 Peoplersquo;s Hospital , Hefei 【Abstract】 Objective To evaluate the efficacy and adverse side effects of oxycodone hydrochloride controlled - release tablets in the treatment of moderate to severe pain in patients with terminal cancer and to observe any improvement on the cancer patients quality of life. Methods Thirty-one patients with moderate or severe cancer pain were treated with oxycodone hydrochloride controlled- release tablets. During the course of treatment, the dosage was adjusted according to the patients desires until the pain completely disappeared or nearly did so. Each patient received the treatment for at least 15 days. At the same time, adverse effects, quality of life and scores for the intensity of pain were observed and recorded. Results The overall rate of relief from pain was 93.5%, among which the rates of excellent, effective and moderate relief were 45.2%, 41.9% and 6.5%, respectively. Oxycodone had mild side effects and quality of life was markedly improved. Conclusions Oxycodone is effective in treatment of moderate and severe cancer pain. The side effects of oxycodone are mild, and the drug can significantly improve the quality of life for patients with cancer pain. 【Key words】 Neoplasms Pain Oxycontin 疼痛是癌症患者中常见的主要症状。对于癌症患者而言,疼痛是最令人恐惧的;而对于医生而言,目前癌痛仍是诊断、治疗过程中最棘手的问