盐酸羟考酮注射液与地佐辛注射液用于腰椎手术术后镇痛效果的比较.docVIP

精品论文 参考文献 盐酸羟考酮注射液与地佐辛注射液用于腰椎手术术后镇痛效果的比较 摘要：目的 比较羟考酮和地佐辛用于腰椎手术术后的镇痛效果。方法 选择择期腰椎全麻手术患者80例，ASAⅠ或Ⅱ级，年龄30～65岁，性别不限，随机分为两组（各40例）：羟考酮组（Ⅰ）和地佐辛组（Ⅱ）。两组患者均于手术结束前15分钟分别给予羟考酮0.1mg/kg，地佐辛0.1mg/kg。观察并记录拔管前5min、拔管时和拔管后5min的平均动脉压（MAP）和心率（HR）。记录患者苏醒时间、术后 2、4、6、24h时疼痛视觉模拟（VAS）评分、以及恶心呕吐、瘙痒、呼吸抑制等不良反应的发生情况。结果 Ⅰ组患者术后2、4、6、24hVAS评分均低于Ⅱ组；Ⅰ组患者恶心呕吐发生率为15%（6例），低于Ⅱ组（40%，16例）；两组患者苏醒期各时间点MAP、HR无统计学差异。结论 羟考酮0.1mg/kg用于腰椎手术术后时，其镇痛效果优于地佐辛0.1mg/kg，且恶心呕吐发生率低。 　　关键词：地佐辛；羟考酮；腰椎手术；镇痛 　　Comparison of postoperative analgesic effect between oxycodone and dezocine in patients lumbar spine surgery operation su hai，yin wei juan，cai liang yu.Traditional Chinese Medicine Hospital of wuxi city，Wuxi 214000，China 　　Abstract：Objective To compare the postoperative analgesic effect of oxycodone and dezocine in patients who underwent lumbar spine surgery operation.Methods A total of 80 cases （aged 30-65 years，ASA Ⅰ-Ⅱ patients of both sexes） suffered lumbar spine surgery were randomly divided into 2 groups，：oxycodone group （groupⅠ） and dezocine group （groupⅡ）.Fifteen minutes before the end of surgery，oxycodone 0.1mg/kg was given in Ⅰgroup，and dezocine 0.1mg/kg was given to Ⅱgroup.Anesthesia was maintained with intraoperative pump injection fentanyl，propofol and sevoflurane inhaled.Observe and record 5min before drawing tube，tube drawing and 5 min after extubation mean arterial pressure （MAP） and heart rate （HR）.Record the duration of extubation，pain of visual analogue scale （VAS） was assessed in 2h.4h.6h and 24h，and the occurrence rate of adverse reactions （nausea，vomit）.Results Ⅰgroup of patients after 2.4.6.24h VAS scores were lower than Ⅱgroup.The incidence of nausea and vomiting in Ⅰgroup of patients was 17.5% （n=7），was lower thanⅡgroup（37.5%，n=15）.There were no significant differences in two groups of patients awakening period each time point MAP，HR.Conclusion the analgesic effect of Oxycodone 0.1mg/kg be used for the lumbar spine surgery operation is better than the dezocine 0.1mg/kg，and the lower incidence of